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Table 1 Hazard ratios for the final model in non-metastatic ccRCC (population-based series)

From: Development of a prognostic risk model for clear cell renal cell carcinoma by systematic evaluation of DNA methylation markers

Marker Values Coef SE HR (95% CI) P-value
Age at diagnosis Continuous (yrs) 0.021 0.023 1.02 (0.98–1.07) 0.36
Gender Male    1 (ref)  
  Female 0.109 0.272 1.11 (0.65–1.90) 0.69
TNM stagea I    1 (ref)  
  II 0.569 0.638 1.77 (0.51–6.17) 0.37
  III 1.207 0.685 3.34 (0.87–12.79) 0.08
  IV 1.884 0.915 6.58 (1.09–39.57) 0.04
Fuhrman grade G1    1 (ref)  
  G2 -0.112 0.426 0.89 (0.39–2.06) 0.79
  G3 -0.047 0.437 0.95 (0.41–2.25) 0.92
  G4 0.955 0.462 2.60 (1.05–6.43) 0.04
Tumor size Continuous (mm) -0.003 0.005 1.00 (0.99–1.01) 0.59
NEFH-ii U    1 (ref)  
  M -0.002 0.298 1.00 (0.56–1.79) 0.99
NEURL-ii U    1 (ref)  
  M 0.475 0.280 1.61 (0.93–2.78) 0.09
LAD1-ii U    1 (ref)  
  M 0.738 0.258 2.07 (1.25–3.43) 0.01
GREM1-ii U    1 (ref)  
  M -0.456 0.284 0.64 (0.36–1.11) 0.11
GATA5 U    1 (ref)  
  M 0.351 0.283 1.43 (0.82–2.49) 0.20
  1. Coef, coefficient; HR, hazard ratio; M, methylated; ref, reference; SE, standard error; TNM, tumor-node-metastasis; U, unmethylated; yrs, years; 95% CI, 95% confidence interval
  2. aTNM stage as defined in 1987