Table 3 Table of used terms, their statistical meaning, and description
Term | Description and usage |
|---|---|
Beta-values | Describe the frequency of methylation at a given CpG site. Numeric values between 0 and 1. Biological interpretable. |
Beta\(_i\) | Single Beta-value i of all p Beta-values |
M-values | Standardized Beta-values. The standardization must be read as “logit” transformation. Numeric values from \(-\infty\) to \(+\infty\). No biological meaning. |
M\(_i\) | Single M-value i of all p M-values |
Outcome | Dependent variable Y of the regression models; here Beta-values or M-values |
\(\Delta _{Beta}\) | Difference in Beta-values |
\(\Delta _{M}\) | Difference in M-values |
\(\beta _0\), \(\beta _1\) | Coefficients of the regression model; \(\beta _0\) as the intercept and \(\beta _1\) as the effect estimate, i.e., the mean difference between the two groups Placebo and Treatment. |