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Table 1 Population characteristics

From: DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

Traits KORA ESTHER-I ESTHER-II NAS WHI JHS
Ethnic background Eur Eur Eur Eur Afr. Am His Eur Afr. Am
N 1725 906 754 1529 1041 607 1449 1677
Age 60.98 (8.88) 62.00 (6.53) 62.76 (6.75) 74.61 (7.05) 61.83 (6.67) 60.93 (6.64) 66.32 (6.73) 56.23 (12.31)
Male 843 (48.9) 435 (48.0) 316 (41.9) 1529 (100) 0 (0) 0 (0) 0 (0) 649 (37.17)
BMI 28.11 (4.78) 27.75 (4.25) 27.47 (4.76) 28.00 (4.13) 31.61 (6.43) 29.21 (5.22) 28.84 (5.83) 32.02 (7.37)
Smoking status
Never smoker 720 (41.7) 443 (48.9) 354 (47.0) 478 (31.3) 496 (48.06) 376 (62.46) 766 (53.34) 1490 (85.88)
Ever smoker 1003 (58.2) 463 (51.1) 400 (53.0) 1051 (68.7) 536 (51.94) 226 (37.54) 670 (46.66) 245 (14.12)
Serum creatinine 0.91 (0.27) 0.69 (0.31) 0.85 (0.31) 1.11 (0.45) 0.82 (0.21) 0.73 (0.23) 0.74 (0.14) 0.96 (0.59)
eGFR 86.77 (16.02) 99.77 (21.15) 86.63 (18.94) 69.32 (16.14) 92.31 (19.65) 88.64 (15.39) 83.69 (13.33) 93.57 (22.37)
CKD 99 (5.7) 54 (5.9) 72 (9.5) 407 (26.6) 59 (5.67) 31 (5.11) 82 (5.66) 115 (6.59)
uACR ** 6.15 (3.85, 11.97) 9.14 (5.49, 17.98) 8.92 (5.34, 16.53) NA NA NA NA 5.95 (3.95,13.23)
Microalbuminuria  150 (8.7) 125 (13.8) 104 (13.8) NA NA NA NA 106 (13.75)
Serum urate 5.37 (1.46) 4.22 (1.49) 4.85 (1.47) 6.13 (1.51) NA NA NA 5.64 (1.70)
Diabetes 158 (9.2) 141 (15.56) 150 (19.89) 235 (15.4) 166 (15.95) 71 (11.70) 96 (6.64) 433 (24.81)
Hypertension 788 (45.7) 516 (55.95) 446 (59.15) 1130 (73.9) 561 (56.21) 207 (35.94) 471 (35.33) 1027 (58.82)
HDL cholesterol 56.47 (14.64) 51.70 (15.79) 53.21 (15.45) 48.81 (12.85) 54.76 (13.78) 51.05 (13.02) 51.38 (11.92) 51.35 (14.73)
Triglycerides ** 110 (77, 158) 89.70 (58.30, 140.50) 111.85 (76.50, 116.30) 114 (83, 158) 104 (75, 141) 140 (105, 188) 133 (95, 184) 92 (64, 129)
C-reactive protein ** 1.27 (0.63, 2.655) 1.62 (0.83, 3.46) 2.40 (1.06, 4.72) 1.47 (0.75, 3.04) NA NA NA 2.71 (1.18, 5.96)
  1. Population characteristics of all participating studies. The means and standards deviation (SD) are shown for continuous traits, and N (%) for categorical traits. **Skewed variables, for which median and (1st, 3rd quartile) are shown. The sample sizes presented here for each of the studies correspond to the number of observations with information on DNAm-predictors, serum-based creatinine kidney traits, chronological age and sex. Age was measured in years at time of participation in study; BMI in kg/m2; serum creatinine in mg/dL; eGFR, serum-creatinine-based estimated glomerular filtration rate in mL/min/1.73 m2; CKD: prevalent chronic kidney disease, defined as eGFR < 60 ml/min/1.73 m2; uACR in mg/g; microalbuminuria was defined as uACR ≥ 30 mg/g; serum urate in mg/dl; prevalent diabetes was defined based on use of glucose lowering drugs or fasting plasma glucose ≥ 126 mg/dl; hypertension defined using the Joint National Committee (JNC) VII definition (blood pressure > 140/90 mm Hg or use of anti-hypertensive medications); HDL cholesterol and triglycerides in mg/dl; C-reactive protein in mg/L; NA denotes the trait was not available. Abbreviations used in ethnic background row: Eur., European ancestry; Afr.Am.., African American; His., Hispanic/Latino. An extended version of this table is shown in Additional file 1: Table S1