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Table 2 Performance metrics of the four clocks in all available tissues

From: Characteristics of epigenetic aging across gestational and perinatal tissues

Cord blood

Bohlin’s clock

Knight’s clock

DNAm GA

\(\Delta\) DNAm GA

r

DNAm GA

\(\Delta\) DNAm GA

r

M

SD

M

SD

MAD

M

SD

M

SD

MAD

ITU

39.80

0.93

− 0.23

0.94

0.92

.83*

38.91

1.47

− 1.13

1.19

1.17

.69*

PREDO (EPIC)

39.72

0.84

− 0.16

0.90

0.98

.80*

39.23

1.39

− 0.64

1.05

0.88

.72*

PREDO (450 K)

38.84

1.14

− 0.90

1.19

1.02

.70*

38.44

2.02

− 1.29

1.90

1.55

.48*

 

Lee’s clock

     

Mayne’s clock

     
 

DNAm GA

 

\(\Delta\) DNAm GA

   

DNAm GA

 

\(\Delta\) DNAm GA

   

Placenta

M

SD

M

SD

MAD

r

M

SD

M

SD

MAD

r

ITU CVS

10.55

1.48

− 2.24

1.14

1.07

.64*

11.69

1.81

− 1.09

1.63

1.57

.43*

ITU Placenta

38.53

1.40

− 1.45

1.41

1.29

.56*

32.68

1.91

− 7.31

1.91

1.73

.28*

PREDO

38.03

1.25

− 1.85

1.24

1.10

.58*

31.69

1.44

− 8.19

1.56

1.63

.41*

  1. M = mean; SD = standard deviation; MAD = median absolute deviation; r = Pearson correlation coefficient for DNAm GA and chronological GA; DNAm GA = DNA methylation gestational age; \(\Delta\) DNAm GA = raw difference between estimated DNA methylation gestational age and chronological gestational age (measured in weeks)
  2. *p < 0.001