Fig. 4

Relationship of epigenetic age acceleration/deceleration between different tissues. In children with more than one tissue available, the relationship of epigenetic age acceleration or deceleration between the respective tissues can be illustrated. Depicted are the scatter plots of EAAR for (a) cord blood and placenta from both ITU (n = 363) and PREDO (n = 116), (b) CVS and placenta from ITU (n = 78), and (c) CVS and cord blood from ITU (n = 66). The regression line is plotted together with a 95% confidence interval, and the Pearson correlation coefficient is depicted. Individual differences in EAARs between CVS, placenta and cord blood from ITU are further illustrated (d) for n = 60 children from ITU, where each color represents one individual.