Fig. 1

Sample overview for both cohorts used. Samples with methylation data available from different tissues in ITU and PREDO. In total, the ITU data set comprised 693 individuals after QC, with 264 CVS, 486 fetal placenta and 426 cord blood samples. For some individuals, samples were available from several tissues, indicated by overlapping circles. The final PREDO data set comprised 171 individuals after QC processed with the EPIC array, and additional 795 individuals processed with the 450 K array. From the EPIC data, 139 samples were available from placenta, and 149 samples from cord blood. The number of individuals with data from both tissues is again illustrated by the overlapping circles