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Table 4 CpGs differentially methylated in association with incident coronary/cardiovascular disease in the fixed-effects meta-analyses of the samples from the Women’s Health Initiative (WHI) and the Framingham Offspring Study (FOS)

From: DNA methylation biomarkers of myocardial infarction and cardiovascular disease

Genomic information     Model 1    Model 2    Model 3   
CpG Chr* Position (bp) Gene Coef* SE* P Coef* SE* P Coef* SE* P
Incident coronary heart disease
cg21566642 2 233,284,661 Intergenic − 1.34 × 10–1 4.33 × 10–2 2.00 × 10–3 − 9.63 × 10–2 4.83 × 10–2 4.62 × 10–2 − 9.66 × 10–2 5.39 × 10–2 7.32 × 10–2
cg05575921 5 373,378 AHRR − 1.80 × 10–1 4.73 × 10–2 1.38 × 10–4 − 1.33 × 10–1 5.81 × 10–2 2.21 × 10–2 − 1.22 × 10–1 6.52 × 10–2 6.05 × 10–2
cg25769469 5 71,643,841 PTCD2 − 2.62 × 10–1 7.94 × 10–2 9.67 × 10–4 − 2.52 × 10–1 8.02 × 10–2 1.70 × 10–3 − 2.14 × 10–1 8.89 × 10–2 1.59 × 10–2
cg04988978 17 56,359,578 MPO − 2.28 × 10–1 7.49 × 10–2 2.29 × 10–3 − 2.07 × 10–1 7.58 × 10–2 6.19 × 10–3 − 1.06 × 10–1 8.35 × 10–2 2.03 × 10–1
Incident cardiovascular disease
cg21566642 2 233,284,661 Intergenic − 1.68 × 10–1 3.97 × 10–2 2.34 × 10–5 − 1.31 × 10–1 4.40 × 10–2 2.94 × 10–3 − 1.37 × 10–1 4.85 × 10–2 4.87 × 10–3
cg05575921 5 373,378 AHRR − 2.08 × 10–1 4.30 × 10–2 1.30 × 10–6 − 1.67 × 10–1 5.24 × 10–2 1.42 × 10–3 − 1.61 × 10–1 5.79 × 10–2 5.54 × 10–3
cg25769469 5 71,643,841 PTCD2 − 1.92 × 10–1 7.27 × 10–2 8.40 × 10–3 − 1.77 × 10–1 7.35 × 10–2 1.58 × 10–2 − 1.26 × 10–1 8.09 × 10–2 1.20 × 10–1
cg04988978 17 56,359,578 MPO − 2.04 × 10–1 6.72 × 10–2 2.42 × 10–3 − 1.83 × 10–1 6.79 × 10–2 6.99 × 10–3 − 9.08 × 10–2 7.36 × 10–2 2.18 × 10–1
  1. *Chr, Chromosome; Coef; Coefficient of association; SE, Standard error
  2. Model 1 was adjusted for age, estimated cell counts and two surrogate variables (plus ancestry in WHI, plus sex in FOS). Model 2 was further adjusted for smoking status. Model 3 was additionally adjusted for diabetes, hypercholesterolemia, and hypertension. The Bonferroni-corrected p threshold was 4.17 × 10–3