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Table 3 CpGs differentially methylated in association with prevalent myocardial infarction in the fixed-effects meta-analyses of the REGICOR case–control samples

From: DNA methylation biomarkers of myocardial infarction and cardiovascular disease

Genomic information Model 1 Model 2 Model 3
CpG Chr* Position (bp) Gene Coef* SE* P Coef* SE* P Coef* SE* P
cg15724772 1 6,373,534 ACOT7 1.17 1.94 × 10–1 1.76 × 10–9 1.16 2.17 × 10–1 8.14 × 10–8 1.00 2.30 × 10–1 1.38 × 10–5
cg11919692 1 26,343,868 Intergenic 1.08 1.98 × 10–1 4.94 × 10–8 1.11 2.19 × 10–1 4.00 × 10–7 1.04 2.34 × 10–1 9.29 × 10–6
cg10636246 1 159,046,973 AIM2 − 0.96 1.41 × 10–1 1.03 × 10–11 − 0.98 1.58 × 10–1 5.21 × 10–10 − 0.86 1.68 × 10–1 3.68 × 10–7
cg08345526 1 226,916,320 ITPKB 1.79 2.93 × 10–1 1.02 × 10–9 1.85 3.29 × 10–1 1.71 × 10–8 1.60 3.45 × 10–1 3.42 × 10–6
cg01552966 2 25,528,330 DNMT3A 1.15 1.93 × 10–1 2.43 × 10–9 1.25 2.22 × 10–1 1.78 × 10–8 1.04 2.33 × 10–1 7.66 × 10–6
cg25420477 2 70,319,121 Intergenic 1.54 2.52 × 10–1 1.08 × 10–9 1.63 2.84 × 10–1 9.01 × 10–9 1.47 3.01 × 10–1 9.45 × 10–7
cg06528771 2 102,513,985 Intergenic − 1.71 2.79 × 10–1 9.88 × 10–10 − 1.89 3.16 × 10–1 2.26 × 10–9 − 1.81 3.48 × 10–1 1.81 × 10–7
cg12206840 2 136,826,451 Intergenic 1.12 1.98 × 10–1 1.31 × 10–8 1.12 2.23 × 10–1 4.89 × 10–7 1.03 2.33 × 10–1 9.08 × 10–6
cg21566642 2 233,284,661 Intergenic − 0.65 1.13 × 10–1 7.70 × 10–9 − 0.30 1.56 × 10–1 5.26 × 10–2 − 0.41 1.70 × 10–1 1.50 × 10–2
cg10650214 3 45,914,188 LZTFL1 1.28 1.97 × 10–1 8.01 × 10–11 1.26 2.19 × 10–1 8.05 × 10–9 1.18 2.31 × 10–1 2.99 × 10–7
cg07386061 3 52,492,874 NISCH 0.99 1.79 × 10–1 2.86 × 10–8 1.03 2.01 × 10–1 3.27 × 10–7 0.86 2.09 × 10–1 4.01 × 10–5
cg13373048 3 71,892,575 Intergenic − 2.76 3.57 × 10–1 1.02 × 10–14 − 3.24 4.23 × 10–1 1.93 × 10–14 − 3.03 4.29 × 10–1 1.77 × 10–12
cg03733470 3 196,613,114 SENP5 − 1.20 2.07 × 10–1 5.94 × 10–9 − 1.28 2.30 × 10–1 2.70 × 10–8 − 1.17 2.46 × 10–1 2.01 × 10–6
cg05575921 5 373,378 AHRR − 0.75 1.25 × 10–1 2.05 × 10–9 − 0.40 1.91 × 10–1 3.48 × 10–2 − 0.45 2.04 × 10–1 2.87 × 10–2
cg25769469 5 71,643,841 PTCD2 − 1.33 2.20 × 10–1 1.33 × 10–9 − 1.38 2.53 × 10–1 5.40 × 10–8 − 1.41 2.80 × 10–1 4.92 × 10–7
cg04725636 8 67,004,538 DNAJC5B − 0.80 1.45 × 10–1 3.33 × 10–8 − 0.72 1.59 × 10–1 5.47 × 10–6 − 0.751 1.74 × 10–1 1.76 × 10–5
cg12066594 9 127,162,066 PSMB7 − 1.89 3.37 × 10–1 2.00 × 10–8 − 2.57 4.07 × 10–1 2.67 × 10–10 − 2.36 4.25 × 10–1 2.83 × 10–8
cg24501073 11 34,210,305 ABTB2 0.99 1.73 × 10–1 1.07 × 10–8 0.98 1.96 × 10–1 6.11 × 10–7 0.82 1.98 × 10–1 3.07 × 10–5
cg02042026 11 113,936,782 ZBTB16 1.04 1.70 × 10–1 8.50 × 10–10 0.99 1.88 × 10–1 1.51 × 10–7 0.98 2.04 × 10–1 1.50 × 10–6
cg01381203 12 2,985,630 FOXM1;RHNO1 − 0.88 1.62 × 10–1 5.17 × 10–8 − 0.84 1.76 × 10–1 1.88 × 10–6 − 0.92 1.95 × 10–1 2.44 × 10–6
cg02175213 12 69,352,407 CPM − 1.08 1.85 × 10–1 5.15 × 10–9 − 1.10 2.06 × 10–1 9.76 × 10–8 − 0.82 2.14 × 10–1 1.27 × 10–4
cg06084585 13 50,797,125 DLEU1 − 1.60 2.87 × 10–1 2.37 × 10–8 − 1.47 3.14 × 10–1 2.96 × 10–6 − 1.36 3.30 × 10–1 3.54 × 10–5
cg15867698 14 69,438,267 ACTN1 1.13 1.86 × 10–1 1.58 × 10–9 1.26 2.14 × 10–1 3.33 × 10–9 1.14 2.25 × 10–1 4.04 × 10–7
cg07252680 14 94,857,224 SERPINA1 − 1.56 2.41 × 10–1 1.17 × 10–10 − 1.43 2.65 × 10–1 6.57 × 10–8 − 1.41 2.86 × 10–1 7.93 × 10–7
cg16125725 15 70,101,302 Intergenic − 2.03 3.45 × 10–1 4.02 × 10–9 − 2.30 3.97 × 10–1 6.82 × 10–9 − 2.20 4.18 × 10–1 1.39 × 10–7
cg09967176 15 77,280,925 Intergenic − 1.28 1.78 × 10–1 6.93 × 10–13 − 1.40 2.03 × 10–1 5.21 × 10–12 − 1.16 2.10 × 10–1 3.82 × 10–8
cg17261469 16 87,420,879 FBXO31 0.99 1.73 × 10–1 9.49 × 10–9 1.00 1.94 × 10–1 3.01 × 10–7 1.00 2.04 × 10–1 9.92 × 10–7
cg04983687 16 88,558,223 ZFPM1 0.72 1.29 × 10–1 2.61 × 10–8 0.68 1.42 × 10–1 1.79 × 10–6 0.44 1.46 × 10–1 2.49 × 10–3
cg22508829 17 17,843,585 TOM1L2 1.28 1.96 × 10–1 7.97 × 10–11 1.35 2.26 × 10–1 2.41 × 10–9 1.10 2.28 × 10–1 1.23 × 10–6
cg22146772 17 26,793,673 Intergenic 1.23 1.97 × 10–1 5.38 × 10–10 1.18 2.22 × 10–1 8.98 × 10–8 1.06 2.28 × 10–1 3.31 × 10–6
cg13064873 17 48,360,726 TMEM92− AS1 − 1.08 1.85 × 10–1 5.31 × 10–9 − 1.19 2.12 × 10–1 1.82 × 10–8 − 1.04 2.23 × 10–1 3.19 × 10–6
cg04988978 17 56,359,578 MPO − 1.31 2.07 × 10–1 2.33 × 10–10 − 1.45 2.37 × 10–1 9.71 × 10–10 − 1.22 2.43 × 10–1 5.41 × 10–7
cg03636183 19 17,000,585 F2RL3 − 0.74 1.36 × 10–1 4.56 × 10–8 − 0.35 1.80 × 10–1 5.24 × 10–2 − 0.39 1.90 × 10–1 4.12 × 10–2
cg19448292 20 35,504,064 C20orf118 1.24 1.93 × 10–1 1.17 × 10–10 1.38 2.25 × 10–1 7.89 × 10–10 1.15 2.30 × 10–1 6.05 × 10–7
  1. *Chr, Chromosome; Coef; Coefficient of association; SE, Standard error
  2. Model 1 was adjusted for estimated cell counts and two surrogate variables. Model 2 was further adjusted for smoking status. Model 3 was additionally adjusted for diabetes, hypercholesterolemia, and hypertension. The Bonferroni-corrected p threshold was 6.17 × 10–8