Table 3 CpGs differentially methylated in association with prevalent myocardial infarction in the fixed-effects meta-analyses of the REGICOR case–control samples
From: DNA methylation biomarkers of myocardial infarction and cardiovascular disease
Genomic information | Model 1 | Model 2 | Model 3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
CpG | Chr* | Position (bp) | Gene | Coef* | SE* | P | Coef* | SE* | P | Coef* | SE* | P |
cg15724772 | 1 | 6,373,534 | ACOT7 | 1.17 | 1.94 × 10–1 | 1.76 × 10–9 | 1.16 | 2.17 × 10–1 | 8.14 × 10–8 | 1.00 | 2.30 × 10–1 | 1.38 × 10–5 |
cg11919692 | 1 | 26,343,868 | Intergenic | 1.08 | 1.98 × 10–1 | 4.94 × 10–8 | 1.11 | 2.19 × 10–1 | 4.00 × 10–7 | 1.04 | 2.34 × 10–1 | 9.29 × 10–6 |
cg10636246 | 1 | 159,046,973 | AIM2 | − 0.96 | 1.41 × 10–1 | 1.03 × 10–11 | − 0.98 | 1.58 × 10–1 | 5.21 × 10–10 | − 0.86 | 1.68 × 10–1 | 3.68 × 10–7 |
cg08345526 | 1 | 226,916,320 | ITPKB | 1.79 | 2.93 × 10–1 | 1.02 × 10–9 | 1.85 | 3.29 × 10–1 | 1.71 × 10–8 | 1.60 | 3.45 × 10–1 | 3.42 × 10–6 |
cg01552966 | 2 | 25,528,330 | DNMT3A | 1.15 | 1.93 × 10–1 | 2.43 × 10–9 | 1.25 | 2.22 × 10–1 | 1.78 × 10–8 | 1.04 | 2.33 × 10–1 | 7.66 × 10–6 |
cg25420477 | 2 | 70,319,121 | Intergenic | 1.54 | 2.52 × 10–1 | 1.08 × 10–9 | 1.63 | 2.84 × 10–1 | 9.01 × 10–9 | 1.47 | 3.01 × 10–1 | 9.45 × 10–7 |
cg06528771 | 2 | 102,513,985 | Intergenic | − 1.71 | 2.79 × 10–1 | 9.88 × 10–10 | − 1.89 | 3.16 × 10–1 | 2.26 × 10–9 | − 1.81 | 3.48 × 10–1 | 1.81 × 10–7 |
cg12206840 | 2 | 136,826,451 | Intergenic | 1.12 | 1.98 × 10–1 | 1.31 × 10–8 | 1.12 | 2.23 × 10–1 | 4.89 × 10–7 | 1.03 | 2.33 × 10–1 | 9.08 × 10–6 |
cg21566642 | 2 | 233,284,661 | Intergenic | − 0.65 | 1.13 × 10–1 | 7.70 × 10–9 | − 0.30 | 1.56 × 10–1 | 5.26 × 10–2 | − 0.41 | 1.70 × 10–1 | 1.50 × 10–2 |
cg10650214 | 3 | 45,914,188 | LZTFL1 | 1.28 | 1.97 × 10–1 | 8.01 × 10–11 | 1.26 | 2.19 × 10–1 | 8.05 × 10–9 | 1.18 | 2.31 × 10–1 | 2.99 × 10–7 |
cg07386061 | 3 | 52,492,874 | NISCH | 0.99 | 1.79 × 10–1 | 2.86 × 10–8 | 1.03 | 2.01 × 10–1 | 3.27 × 10–7 | 0.86 | 2.09 × 10–1 | 4.01 × 10–5 |
cg13373048 | 3 | 71,892,575 | Intergenic | − 2.76 | 3.57 × 10–1 | 1.02 × 10–14 | − 3.24 | 4.23 × 10–1 | 1.93 × 10–14 | − 3.03 | 4.29 × 10–1 | 1.77 × 10–12 |
cg03733470 | 3 | 196,613,114 | SENP5 | − 1.20 | 2.07 × 10–1 | 5.94 × 10–9 | − 1.28 | 2.30 × 10–1 | 2.70 × 10–8 | − 1.17 | 2.46 × 10–1 | 2.01 × 10–6 |
cg05575921 | 5 | 373,378 | AHRR | − 0.75 | 1.25 × 10–1 | 2.05 × 10–9 | − 0.40 | 1.91 × 10–1 | 3.48 × 10–2 | − 0.45 | 2.04 × 10–1 | 2.87 × 10–2 |
cg25769469 | 5 | 71,643,841 | PTCD2 | − 1.33 | 2.20 × 10–1 | 1.33 × 10–9 | − 1.38 | 2.53 × 10–1 | 5.40 × 10–8 | − 1.41 | 2.80 × 10–1 | 4.92 × 10–7 |
cg04725636 | 8 | 67,004,538 | DNAJC5B | − 0.80 | 1.45 × 10–1 | 3.33 × 10–8 | − 0.72 | 1.59 × 10–1 | 5.47 × 10–6 | − 0.751 | 1.74 × 10–1 | 1.76 × 10–5 |
cg12066594 | 9 | 127,162,066 | PSMB7 | − 1.89 | 3.37 × 10–1 | 2.00 × 10–8 | − 2.57 | 4.07 × 10–1 | 2.67 × 10–10 | − 2.36 | 4.25 × 10–1 | 2.83 × 10–8 |
cg24501073 | 11 | 34,210,305 | ABTB2 | 0.99 | 1.73 × 10–1 | 1.07 × 10–8 | 0.98 | 1.96 × 10–1 | 6.11 × 10–7 | 0.82 | 1.98 × 10–1 | 3.07 × 10–5 |
cg02042026 | 11 | 113,936,782 | ZBTB16 | 1.04 | 1.70 × 10–1 | 8.50 × 10–10 | 0.99 | 1.88 × 10–1 | 1.51 × 10–7 | 0.98 | 2.04 × 10–1 | 1.50 × 10–6 |
cg01381203 | 12 | 2,985,630 | FOXM1;RHNO1 | − 0.88 | 1.62 × 10–1 | 5.17 × 10–8 | − 0.84 | 1.76 × 10–1 | 1.88 × 10–6 | − 0.92 | 1.95 × 10–1 | 2.44 × 10–6 |
cg02175213 | 12 | 69,352,407 | CPM | − 1.08 | 1.85 × 10–1 | 5.15 × 10–9 | − 1.10 | 2.06 × 10–1 | 9.76 × 10–8 | − 0.82 | 2.14 × 10–1 | 1.27 × 10–4 |
cg06084585 | 13 | 50,797,125 | DLEU1 | − 1.60 | 2.87 × 10–1 | 2.37 × 10–8 | − 1.47 | 3.14 × 10–1 | 2.96 × 10–6 | − 1.36 | 3.30 × 10–1 | 3.54 × 10–5 |
cg15867698 | 14 | 69,438,267 | ACTN1 | 1.13 | 1.86 × 10–1 | 1.58 × 10–9 | 1.26 | 2.14 × 10–1 | 3.33 × 10–9 | 1.14 | 2.25 × 10–1 | 4.04 × 10–7 |
cg07252680 | 14 | 94,857,224 | SERPINA1 | − 1.56 | 2.41 × 10–1 | 1.17 × 10–10 | − 1.43 | 2.65 × 10–1 | 6.57 × 10–8 | − 1.41 | 2.86 × 10–1 | 7.93 × 10–7 |
cg16125725 | 15 | 70,101,302 | Intergenic | − 2.03 | 3.45 × 10–1 | 4.02 × 10–9 | − 2.30 | 3.97 × 10–1 | 6.82 × 10–9 | − 2.20 | 4.18 × 10–1 | 1.39 × 10–7 |
cg09967176 | 15 | 77,280,925 | Intergenic | − 1.28 | 1.78 × 10–1 | 6.93 × 10–13 | − 1.40 | 2.03 × 10–1 | 5.21 × 10–12 | − 1.16 | 2.10 × 10–1 | 3.82 × 10–8 |
cg17261469 | 16 | 87,420,879 | FBXO31 | 0.99 | 1.73 × 10–1 | 9.49 × 10–9 | 1.00 | 1.94 × 10–1 | 3.01 × 10–7 | 1.00 | 2.04 × 10–1 | 9.92 × 10–7 |
cg04983687 | 16 | 88,558,223 | ZFPM1 | 0.72 | 1.29 × 10–1 | 2.61 × 10–8 | 0.68 | 1.42 × 10–1 | 1.79 × 10–6 | 0.44 | 1.46 × 10–1 | 2.49 × 10–3 |
cg22508829 | 17 | 17,843,585 | TOM1L2 | 1.28 | 1.96 × 10–1 | 7.97 × 10–11 | 1.35 | 2.26 × 10–1 | 2.41 × 10–9 | 1.10 | 2.28 × 10–1 | 1.23 × 10–6 |
cg22146772 | 17 | 26,793,673 | Intergenic | 1.23 | 1.97 × 10–1 | 5.38 × 10–10 | 1.18 | 2.22 × 10–1 | 8.98 × 10–8 | 1.06 | 2.28 × 10–1 | 3.31 × 10–6 |
cg13064873 | 17 | 48,360,726 | TMEM92− AS1 | − 1.08 | 1.85 × 10–1 | 5.31 × 10–9 | − 1.19 | 2.12 × 10–1 | 1.82 × 10–8 | − 1.04 | 2.23 × 10–1 | 3.19 × 10–6 |
cg04988978 | 17 | 56,359,578 | MPO | − 1.31 | 2.07 × 10–1 | 2.33 × 10–10 | − 1.45 | 2.37 × 10–1 | 9.71 × 10–10 | − 1.22 | 2.43 × 10–1 | 5.41 × 10–7 |
cg03636183 | 19 | 17,000,585 | F2RL3 | − 0.74 | 1.36 × 10–1 | 4.56 × 10–8 | − 0.35 | 1.80 × 10–1 | 5.24 × 10–2 | − 0.39 | 1.90 × 10–1 | 4.12 × 10–2 |
cg19448292 | 20 | 35,504,064 | C20orf118 | 1.24 | 1.93 × 10–1 | 1.17 × 10–10 | 1.38 | 2.25 × 10–1 | 7.89 × 10–10 | 1.15 | 2.30 × 10–1 | 6.05 × 10–7 |