Table 2 Descriptive characteristics of the populations used in the follow-up association studies on incident cardiovascular (CVD) and coronary heart disease (CHD) events: Women’s Health Initiative (WHI) and Framingham Offspring Study (FOS)
From: DNA methylation biomarkers of myocardial infarction and cardiovascular disease
Variables | WHI | FOS CHD | FOS CVD | |||
|---|---|---|---|---|---|---|
N = 1863 | NA | N = 2266 | NA | N = 2123 | NA | |
Age | 64.2 (7.03) | 0 | 65.7 (8.82) | 0 | 65.3 (8.66) | 0 |
Sex, female, n (%) | 1863 (100) | 0 | 1284 (56.7) | 0 | 1206 (56.8) | 0 |
CHD, n (%)‡ | 914 (49.1) | 0 | 106 (4.68) | 0 | _ | _ |
CVD, n (%)‡ | 984 (52.8) | 0 | _ | _ | 222 (10.5) | 0 |
Smokers, n (%) | 174 (9.46) | 24 | 217 (9.62) | 11 | 202 (9.56) | 11 |
BMI, kg/m2*‡ | 29.8 (5.97) | 11 | 28.1 (5.39) | 8 | 28.0 (5.33) | 6 |
Total cholesterol, mg/dl* | 233 (42.3) | 1 | 189 (36.2) | 1 | 190 (35.8) | 1 |
LDL-C, mg/dl*‡ | 152 (38.7) | 31 | 107 (30.8) | 2 | 108 (30.5) | 2 |
HDL-C, mg/dl*‡ | 52.2 (13.2) | 1 | 58.3 (18.3) | 2 | 58.7 (18.3) | 2 |
TG, mg/d† | 126 [93.0;176] | 1 | 101 [73.0;140] | 1 | 100 [73.0;139] | 1 |
SBP, mmHg*‡ | 131 (17.5) | 0 | 126 (16.9) | 1 | 125 (16.7) | 1 |
DBP, mmHg*‡ | 76.4 (9.27) | 0 | 72.1 (9.99) | 3 | 72.3 (9.92) | 3 |
HTN treatment, n (%)‡ | 672 (45.9) | 400 | 1025 (45.4) | 7 | 927 (43.8) | 6 |
Glucose, mg/dl† | 107 (38.3) | 1 | 106 (21.8) | 2 | 105 (21.5) | 2 |
Diabetes, n (%) | 319 (17.1) | 0 | 307 (14.3) | 126 | 266 (13.3) | 119 |