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Table 1 Descriptive characteristics of the populations used in the two-stage EWAS on acute myocardial infarction (AMI): REGICOR-1 and REGICOR-2

From: DNA methylation biomarkers of myocardial infarction and cardiovascular disease

Variables Discovery: REGICOR-1 Validation: REGICOR-2
N = 391 NA‡ N = 204 NA‡
AMI cases/controls, n (%)‡     
AMI cases 196 (50.1) 0 101 (49.5) 0
Controls 195 (49.9) 0 103 (50.5) 0
Age 63.2 (6.94) 0 61.7 (6.90) 0
AMI cases 63.0 (6.96) 0 61.6 (6.83) 0
Controls 63.3 (6.94) 0 61.7 (7.01) 0
Sex, female, n (%) 201 (51.4) 0 100 (49.0) 0
AMI cases 100 (51.0) 0 49 (48.5) 0
Controls 101 (51.8) 0 51 (49.5) 0
Smokers, n (%) 93 (24.4) 10 67 (33.3) 3
AMI cases 76 (40.6) 9 45 (45.0) 1
Controls 17 (8.76) 1 22 (21.8) 2
BMI, kg/m2*‡ 28.5 (4.75) 52 27.5 (4.87) 23
AMI cases 28.1 (4.34) 52 28.2 (5.87) 23
Controls 28.8 (5.02) 0 26.9 (3.90) 0
Hypercholesterolaemia, n (%)‡ 179 (53.0) 53 93 (51.4) 23
AMI cases 93 (64.1) 51 51 (65.4) 23
Controls 86 (44.6) 2 42 (40.8) 0
HTN, n (%)‡ 212 (57.1) 20 105 (54.1) 10
AMI cases 120 (68.2) 20 62 (68.1) 10
Controls 92 (47.2) 0 43 (41.7) 0
Diabetes, n (%) 87 (24.7) 39 44 (23.8) 19
AMI cases 56 (35.7) 39 27 (32.9) 19
Controls 31 (15.9) 0 17 (16.5) 0
  1. NA, missing information; AMI, Acute myocardial infarction; BMI, Body mass index; Hypercholesterolaemia, defined as self-reported high cholesterol levels or treatment; HTN, Hypertension, defined as self-reported high blood pressure or treatment; Diabetes, defined as self-reported diabetes or treatment
  2. Median (Interquartile Range)
  3. *Mean (Standard deviation)