Table 1 Descriptive characteristics of the populations used in the two-stage EWAS on acute myocardial infarction (AMI): REGICOR-1 and REGICOR-2
From: DNA methylation biomarkers of myocardial infarction and cardiovascular disease
Variables | Discovery: REGICOR-1 | Validation: REGICOR-2 | ||
|---|---|---|---|---|
N = 391 | NA‡ | N = 204 | NA‡ | |
AMI cases/controls, n (%)‡ | ||||
AMI cases | 196 (50.1) | 0 | 101 (49.5) | 0 |
Controls | 195 (49.9) | 0 | 103 (50.5) | 0 |
Age | 63.2 (6.94) | 0 | 61.7 (6.90) | 0 |
AMI cases | 63.0 (6.96) | 0 | 61.6 (6.83) | 0 |
Controls | 63.3 (6.94) | 0 | 61.7 (7.01) | 0 |
Sex, female, n (%) | 201 (51.4) | 0 | 100 (49.0) | 0 |
AMI cases | 100 (51.0) | 0 | 49 (48.5) | 0 |
Controls | 101 (51.8) | 0 | 51 (49.5) | 0 |
Smokers, n (%) | 93 (24.4) | 10 | 67 (33.3) | 3 |
AMI cases | 76 (40.6) | 9 | 45 (45.0) | 1 |
Controls | 17 (8.76) | 1 | 22 (21.8) | 2 |
BMI, kg/m2*‡ | 28.5 (4.75) | 52 | 27.5 (4.87) | 23 |
AMI cases | 28.1 (4.34) | 52 | 28.2 (5.87) | 23 |
Controls | 28.8 (5.02) | 0 | 26.9 (3.90) | 0 |
Hypercholesterolaemia, n (%)‡ | 179 (53.0) | 53 | 93 (51.4) | 23 |
AMI cases | 93 (64.1) | 51 | 51 (65.4) | 23 |
Controls | 86 (44.6) | 2 | 42 (40.8) | 0 |
HTN, n (%)‡ | 212 (57.1) | 20 | 105 (54.1) | 10 |
AMI cases | 120 (68.2) | 20 | 62 (68.1) | 10 |
Controls | 92 (47.2) | 0 | 43 (41.7) | 0 |
Diabetes, n (%) | 87 (24.7) | 39 | 44 (23.8) | 19 |
AMI cases | 56 (35.7) | 39 | 27 (32.9) | 19 |
Controls | 31 (15.9) | 0 | 17 (16.5) | 0 |