Fig. 7

A model that explains the mechanism underlying CPEB1 hypermethylation. The schematic diagram presented that epigenetic silencing of CPEB1 enhances the capacity for malignant metastasis by reducing chromatin accessibility and thus CEBPB binding in colorectal cancer cells. a In healthy tissues, CEBPB binds to the CPEB1 upstream region to initiate CPEB1 transcription. b In CRC tissues, the core TF-binding region of CPEB1 is hypermethylated and thus inaccessible and unable to support CEBPB binding. However, the methylation reader TFCP2 can recognise and bind to the hypermethylated CPEB1 core TF-binding region, thereby suppressing CPEB1 expression and contributing to the potential for metastasis