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Fig. 1 | Clinical Epigenetics

Fig. 1

From: DNA hypermethylation contributes to colorectal cancer metastasis by regulating the binding of CEBPB and TFCP2 to the CPEB1 promoter

Fig. 1

Hypermethylation of CPEB1 in colorectal cancer. a The mean methylation values (β values) of each CpG site located at the TSS1500 of CPEB1 in CRC tumours and para-tumour tissue identified in TCGA. The error bars represent the 95% confidence intervals (95% CIs) of the β values; TSS, transcription start site. b The average β value of all CpG sites located at the TSS1500 of CPEB1 for each CRC tumour/para-tumour tissue from TCGA. c The mean methylation values (β value) of each CpG site located within our targeted region of CPEB1 for each sample in our validation cohort (n = 104). The error bars represent 95% CIs of the β values. d The average β value of all CpG sites located within our targeted region for each CRC tumour/para-tumour tissue from the samples in our validation cohort (n = 104). e Overall ROC (receiver operating characteristics) calculated through a logistic regression model using all detected CpG sites at CPEB1 TSS1500 included as the variables. f The mean methylation level of CpG sites located at the SEPTIN9 promoter in the CRC tumours and para-tumours tissue in our validation cohort (n = 104). The methylation status of the SEPTIN9 promoter served as a technical control, as methylation of this region is known to be increased in CRC compared with normal tissues

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