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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC

Fig. 3

NDRG4 methylation and FIT performance in fecal DNA and combined with the previously established marker panel. a ROC curve for NDRG4. The jagged (green) lines indicate the ROC curve. The gray line represents the line of no discrimination between good and bad classification. b Methylation frequency (%) of NDRG4 methylation markers in fecal DNA of healthy controls (white bar) and carcinomas (dark gray bar). Pearson’s chi-square test was used to calculate P value. c The performance of FIT within the study population containing normal (n = 50) and carcinoma (n = 43) samples. d ROC curve for FIT alone and for FIT with GDNF/SNAP91/NDRG4. The green lines indicate the ROC curve for FIT alone while the purple line indicates the ROC for FIT/NDRG4/SNAP91. The gray line represents the line of no discrimination between good and bad classification. e, f The best performing marker panels GDNF/SNAP91/NDRG4 (e) and SNAP91/NDRG4 (f) in combination with FIT. For all figures, the 95% CI is shown with the error bars. Pearson’s chi-square test was used to calculate P values

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