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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Methylation of SERPINA1 gene promoter may predict chronic obstructive pulmonary disease in patients affected by acute coronary syndrome

Fig. 3

a Acute coronary syndrome (ACS) patient’s stratification according to the number of CpGs methylated in SERPINA1, i.e., hypermethylation and hypomethylation. Methylated and unmethylated CpG-6 in SERPINA1 hypermethylated and hypomethylated samples, respectively, are reported. Samples showing more than or equal to 5 out of 8 (≥ 50%) methylated CpG dinucleotides were considered hypermethylated. Filled-in and clear circles represent methylated and unmethylated CpGs, respectively. The CpGs within the SERPINA1 promoter are numbered across the top of the grid. Each row represents one PCR product/analyzed sequence. Vertical red box highlights CpG-6 dinucleotides across hypermethylated and hypomethylated samples. b Frequencies of methylated CpG-6 in SERPINA1 promoter hypermethylated and hypomethylated ACS samples. ****p < 0.0001

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Clinical Epigenetics

ISSN: 1868-7083

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