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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Methylation of SERPINA1 gene promoter may predict chronic obstructive pulmonary disease in patients affected by acute coronary syndrome

Fig. 1

a Genomic structure of chromosome 14, SERPINA1 gene and SERPINA1 promoter region. Upper line: graphical representation of chromosome 14. SERPINA1 gene is located on the long arm of the chromosome at 14q32.1. Middle line: graphical representation of SERPINA1 gene (GenBank accession number NG_008290.1). The gene includes seven exons (Ia-Ic, II, III, IV and V) and six introns. Filled-in boxes and horizontal arrow indicate gene exons and orientation, respectively. Bottom line: analyzed SERPINA1 promoter sequence with 8 CpGs including the 6th CpG of the amplified region located at the CG-box consensus sequence. The horizontal arrows represent the primers. b Bisulfite PCR of SERPINA1 promoter region. MW, molecular weight; NTC, no template control. Columns 1–13, representative bisulfite-treated DNAs from acute coronary syndrome (ACS) patients with chronic obstructive pulmonary disease (COPD+, columns 1–6) and without COPD (COPD−, columns 7–13)

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Clinical Epigenetics

ISSN: 1868-7083

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