Table 2 Association of the MOFA factors and cardiovascular disease risk (Cox regression): Model 1, adjusted for cell-type counts and one surrogate variable; Model 2, additionally adjusted for age and sex; Model 3, additionally adjusted for total cholesterol, HDL-C levels, glucose, smoking status and systolic and diastolic blood pressure
From: DNA methylation and gene expression integration in cardiovascular disease
Model | Association with CVD incidence | Predictive capacity of the Framingham CVR function | ||||||
|---|---|---|---|---|---|---|---|---|
HRa (95% CIa) | p-value | FDR correction | C-statistic classical function | C-statistic classical function + factor | p-valueCa | NRIa (95% CI) | Clinical NRIa (95% CIa) | |
F9a—Model 1 | 2.05 (1.69, 2.48) | 3.04 × 10−13 | 9.44 × 10−12 | – | – | – | – | – |
F9—Model 2 | 1.56 (1.26, 1.93) | 3.48 × 10−5 | 2.7 × 10−4 | – | – | – | – | – |
F9—Model 3 | 1.42 (1.15, 1.77) | 1.37 × 10−3 | 8.46 × 10−3 | 0.73 | 0.73 | 0.97 | − 2.12 (− 8.17, 3.89) | − 2.38 (− 10.74, 5.98) |
F19a—Model 1 | 1.42 (1.26, 1.61) | 9.10 × 10−9 | 7.05 × 10−8 | – | – | – | – | – |
F19—Model 2 | 1.21 (1.06, 1.38) | 4.61 × 10−3 | 2.38 × 10−2 | – | – | – | – | – |
F19—Model 3 | 1.20 (1.05, 1.37) | 9 × 10−3 | 4.65 × 10−2 | 0.73 | 0.74 | 0.20 | 0.21 (− 8.01, 8.01) | 1.85 (− 8.83, 12.54) |
F21a Ma—Model 1 | 1.24 (1.02, 1.51) | 3.22 × 10−2 | 6.65 × 10−2 | – | – | – | – | – |
F21 M—Model 2 | 1.21 (1.00, 1.48) | 5.56 × 10−2 | 0.13 | – | – | – | – | – |
F21 M—Model 3 | 1.21 (0.99, 1.48) | 6.38 × 10−2 | 0.15 | 0.71 | 0.72 | 0.30 | 2.92 (− 8.03, 13.49) | 6.61 (− 9.53, 22.76) |
F21 Wa—Model 1 | 1.81 (1.44, 2.29) | 5.52 × 10−7 | 3.42 × 10−6 | – | – | – | – | – |
F21 W—Model 2 | 1.71 (1.36, 2.15) | 5.54 × 10−6 | 5.72 × 10−5 | – | – | – | – | – |
F21 W—Model 3 | 1.77 (1.39, 2.24) | 2.40 × 10−6 | 3.72 × 10−5 | 0.75 | 0.79 | 0.01 | 20.85 (5.04, 37.38) | 24.00 (4.55, 43.43) |
F27a—Model 1 | 1.38 (1.25, 1.53) | 5.98 × 10−10 | 9.28 × 10−9 | – | – | – | – | – |
F27—Model 2 | 1.38 (1.25, 1.54) | 4.48 × 10−10 | 1.39 × 10−8 | – | – | – | – | – |
F27—Model 3 | 1.36 (1.22, 1.51) | 1.08 × 10−8 | 3.35 × 10−7 | 0.73 | 0.75 | 0.01 | 1.23 (− 6.48, 8.44) | 4.90 (− 4.37, 14.17) |