Associations among phthalate exposure, DNA methylation of TSLP, and childhood allergy

Clinical Epigenetics

Table 2 Concentration of PAEs, DNA methylation, and RNA levels

	N (total)	Positive detection*
	N (total)	N^Δ	Median (range)
Parental compounds of phthalates (μg/g dust)^#
DMP	87	11	2.43 (1.98–18.87)
DEP	87	16	3.08 (2.12–8.93)
DBP	78	78	18.61 (5.26–159.75)
BBzP	84	55	6.11 (1.94–48.53)
DEHP	85	85	909.03 (78.98–2769.2)
Metabolism of phthalates (μg/g Cr)^¥
MMP	90	90	6.64 (1.11–188.64)
MEP	90	90	15.60 (2.29–540.08)
MBP	90	90	52.76 (17.28–445.56)
MBzP	90	90	5.31 (0.97–217.16)
MEHP	90	90	10.11 (1.79–361.44)
MEHHP	90	90	45.12 (10.17–2276.0)
MEOHP	90	90	42.62 (10.21–1769.9)
Cytokine (pg/ml)^†
IL-4	90	11	1.77 (1.14–12.44)
IL-5	90	47	1.51 (1.03–3.88)
IL-6	90	20	1.78 (1.15–9.78)
IL-8	90	81	2.12 (1.10–7.90)
IL-12	90	12	1.51 (1.11–8.52)
IL-13	90	16	1.92 (1.16–11.09)
IFN-r	90	44	1.56 (1.02–24.99)
TNF-α	90	39	1.72 (1.12–4.01)
DNA methylation percentage of TSLP promoter (%)
Position − 775	90	90	17 (7–27)
mRNA expression level^¶
TSLP	90	18	9.71 (0.08–1931.49)

^*Samples with levels within the concentration range of calibration curve
^ΔThe number of samples with quantifiable concentrations (i.e., within the calibration range)
^#The parental compounds of phthalates were analysis from settle dust samples
^¥The metabolism of phthalates were analysis from urine samples
^†Cytokine were analysis from serum samples
^¶Percent of reference/housekeeping genes (Actin Beta (ACTB))

ISSN: 1868-7083