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Fig. 6 | Clinical Epigenetics

Fig. 6

From: The impact of CBP expression in estrogen receptor-positive breast cancer

Fig. 6

Expression of CBP and GCN5 in clinical breast tumors. a 388 and 391 samples were analyzed by immunohistochemistry for the expression of CBP and GCN5, respectively. Samples were scored using immunoreactivity scoring system (IRS) and designated as negative (IRSā€‰=ā€‰0ā€“3), weakly positive (IRSā€‰=ā€‰4ā€“5), moderately positive (IRSā€‰=ā€‰6ā€“7) and strongly positive (IRSā€‰=ā€‰8ā€“9). b, c Immunohistochemistry analysis of b CBP and c GCN5 expressions in normal, benign lesion and breast carcinoma tissues of breast cancer patients. *pā€‰<ā€‰0.05, Pearson Chi-Square test. d Publicly available dataset of breast cancer patients were acquired from METABRIC database for different types of breast cancer. e The patients with ductal carcinoma (nā€‰=ā€‰1863) were filtrated for genetic alterations analysis of CREBBP and KAT2A genes. f, g Pie Charts for the amplification of f CREBBP gene and g KAT2A gene in ductal carcinoma patients from METABRIC database

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