TY - JOUR AU - Ramadan, Wafaa S. AU - Talaat, Iman M. AU - Hachim, Mahmood Y. AU - Lischka, Annette AU - Gemoll, Timo AU - El-Awady, Raafat PY - 2021 DA - 2021/04/07 TI - The impact of CBP expression in estrogen receptor-positive breast cancer JO - Clinical Epigenetics SP - 72 VL - 13 IS - 1 AB - The development of new biomarkers with diagnostic, prognostic and therapeutic prominence will greatly enhance the management of breast cancer (BC). Several reports suggest the involvement of the histone acetyltransferases CREB-binding protein (CBP) and general control non-depressible 5 (GCN5) in tumor formation; however, their clinical significance in BC remains poorly understood. This study aims to investigate the value of CBP and GCN5 as markers and/or targets for BC prognosis and therapy. Expression of CBP, GCN5, estrogen receptor α (ERα), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) in BC was analyzed in cell lines by western blot and in patients’ tissues by immunohistochemistry. The gene amplification data were also analyzed for CBP and GCN5 using the publicly available data from BC patients. SN - 1868-7083 UR - https://doi.org/10.1186/s13148-021-01060-2 DO - 10.1186/s13148-021-01060-2 ID - Ramadan2021 ER -