From: The dark side of histones: genomic organization and role of oncohistones in cancer
Gene name* | Histone protein codified | Gene chromosomal location | Expression | Function | References | |
---|---|---|---|---|---|---|
Canonical H2B core histones | ||||||
1 | HIST1H2BA (or TSH2B) | H2B type 1-A (or TSH2B.1)§ | 6p22.2 (in histone cluster 1) | Replication-dependent and tissue-specific (testis/sperm-specific) | Not determined | [32] |
2 | HIST1H2BB | H2B type 1-B | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
3 | HIST1H2BC | H2B type 1-C/E/F/G/I | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
4 | HIST1H2BE | |||||
5 | HIST1H2BF | |||||
6 | HIST1H2BG | |||||
7 | HIST1H2BI | |||||
8 | HIST1H2BD | H2B type 1-D | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
9 | HIST1H2BH | H2B type 1-H | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
10 | HIST1H2BJ | H2B type 1-J | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
11 | HIST1H2BK | H2B type 1-K | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
12 | HIST1H2BL | H2B type 1-L | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
13 | HIST1H2BM | H2B type 1-M | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
14 | HIST1H2BN | H2B type 1-N | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
15 | HIST1H2BO | H2B type 1-O | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
16 | HIST2H2BB (pseudogene) | 1q21.1 (in histone cluster 2) | ||||
17 | HIST2H2BC (pseudogene) | 1q21.2 (in histone cluster 2) | ||||
18 | HIST2H2BD (pseudogene) | 1q21.2 (in histone cluster 2) | ||||
19 | HIST2H2BE | H2B type 2-E | 1q21.2 (in histone cluster 2) | Replication-dependent | Core component of nucleosome | [18] |
20 | HIST2H2BF | H2B type 2-F | 1q21.2 (in histone cluster 2) | Replication-dependent | Core component of nucleosome | [18] |
21 | HIST3H2BA (pseudogene) | 1q42.13 (in histone cluster 3) | ||||
22 | HIST3H2BB | H2B type 3-B | 1q42.13 (in histone cluster 3) | Replication-dependent | Core component of nucleosome | [18] |
Non-canonical H2B core histones | ||||||
1 | H2BW1 | H2B.W | Xq22.2 | Replication-independent and tissue-specific (testis/sperm-specific) | Involvement in telomere function. Unlike conventional H2B, H2B.W1 does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes | [33] |