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Table 2 Human canonical and non-canonical core histones of the H2B family with their chromosomal location, expression and function

From: The dark side of histones: genomic organization and role of oncohistones in cancer

 

Gene name*

Histone protein codified

Gene chromosomal location

Expression

Function

References

Canonical H2B core histones

1

HIST1H2BA (or TSH2B)

H2B type 1-A (or TSH2B.1)§

6p22.2 (in histone cluster 1)

Replication-dependent and tissue-specific (testis/sperm-specific)

Not determined

[32]

2

HIST1H2BB

H2B type 1-B

6p22.2 (in histone cluster 1)

Replication-dependent

Core component of nucleosome

[18]

3

HIST1H2BC

H2B type 1-C/E/F/G/I

6p22.2 (in histone cluster 1)

Replication-dependent

Core component of nucleosome

[18]

4

HIST1H2BE

5

HIST1H2BF

6

HIST1H2BG

7

HIST1H2BI

8

HIST1H2BD

H2B type 1-D

6p22.2 (in histone cluster 1)

Replication-dependent

Core component of nucleosome

[18]

9

HIST1H2BH

H2B type 1-H

6p22.2 (in histone cluster 1)

Replication-dependent

Core component of nucleosome

[18]

10

HIST1H2BJ

H2B type 1-J

6p22.1 (in histone cluster 1)

Replication-dependent

Core component of nucleosome

[18]

11

HIST1H2BK

H2B type 1-K

6p22.1 (in histone cluster 1)

Replication-dependent

Core component of nucleosome

[18]

12

HIST1H2BL

H2B type 1-L

6p22.1 (in histone cluster 1)

Replication-dependent

Core component of nucleosome

[18]

13

HIST1H2BM

H2B type 1-M

6p22.1 (in histone cluster 1)

Replication-dependent

Core component of nucleosome

[18]

14

HIST1H2BN

H2B type 1-N

6p22.1 (in histone cluster 1)

Replication-dependent

Core component of nucleosome

[18]

15

HIST1H2BO

H2B type 1-O

6p22.1 (in histone cluster 1)

Replication-dependent

Core component of nucleosome

[18]

16

HIST2H2BB (pseudogene)

 

1q21.1 (in histone cluster 2)

   

17

HIST2H2BC (pseudogene)

 

1q21.2 (in histone cluster 2)

   

18

HIST2H2BD (pseudogene)

 

1q21.2 (in histone cluster 2)

   

19

HIST2H2BE

H2B type 2-E

1q21.2 (in histone cluster 2)

Replication-dependent

Core component of nucleosome

[18]

20

HIST2H2BF

H2B type 2-F

1q21.2 (in histone cluster 2)

Replication-dependent

Core component of nucleosome

[18]

21

HIST3H2BA (pseudogene)

 

1q42.13 (in histone cluster 3)

   

22

HIST3H2BB

H2B type 3-B

1q42.13 (in histone cluster 3)

Replication-dependent

Core component of nucleosome

[18]

Non-canonical H2B core histones

1

H2BW1

H2B.W

Xq22.2

Replication-independent and tissue-specific (testis/sperm-specific)

Involvement in telomere function. Unlike conventional H2B, H2B.W1 does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes

[33]

  1. *The gene names of canonical histones are composed by a first part referring to their histone cluster, followed by the type of histone and, finally, by a letter, designated in alphabetical order for each histone type, based on the distance from the telomere
  2. §These isoforms are testis-specific variants