Fig. 3
From: The dark side of histones: genomic organization and role of oncohistones in cancer
Proposed mechanisms of the main histone H3 mutations. H3K27M leads to a loss of H3K27me3 and H3K27me2 by acting as a dominant-negative inhibitor of PRC2, the complex responsible for H3K27 methylation. H3K36M oncohistone binds and dominantly inhibits the activity of SETD2, the histone methyltransferase responsible for H3K36 methylation. Methylation of H3K36 is known to antagonize the function of PRC2. H3G34 mutants block SETD2 binding, thus reducing its activity on H3K36 methylation. Mutations are indicated in red circles; methyl groups are shown as green circles