Fig. 2From: The dark side of histones: genomic organization and role of oncohistones in cancerLocalization of cancer-associated histone mutations. The most relevant somatic missense histone mutations for each core histone family are shown (red circles). Mutations were considered relevant depending on their recurrence in cross-cancer mutation summaries using cBioPortal and/or on the basis of the existence of studies that investigated their functional role. Globular domains are indicated by blue bars; sites of known PTMs are indicated by green circles. N-tt, N-terminal tail; C-tt, C-terminal tailBack to article page