Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood

Table 2 Family emotional health (FEH) predicts hemisphere-specific brain region volume (BRV) (n = 98)

L. hipp vol. (mm³)	Adj. R²	RSE	b	SE	R. hipp vol. (mm³)	Adj. R²	RSE	b	SE
Model	0.325***	369.2			Model	0.532***	255.9
FEH			2.6	5.2	FEH			10.4**	3.6
Sex (female)			− 60.6	114.9	Sex (female)			− 88.5	79.7
Age			− 32.1	33.2	Age			− 8.4	23.0
Cumulative impact of past year SLE			− 2.5	5.9	Cumulative impact of past year SLE			4.1	4.1
Total brain volume (mm³)			0.002***	0.0005	Total brain volume (mm³)			0.002***	0.0003

L. dlPFC vol. (mm³)	Adj. R²	RSE	b	SE	R. dlPFC vol. (mm³)	Adj. R²	RSE	b	SE
Model	0.564***	1182.0			Model	0.344**	1254.0
FEH			− 27.9	16.7	FEH			− 8.8	17.7
Sex (female)			366.8	367.9	Sex (female)			219.2	390.3
Age			− 82.5	106.3	Age			− 323.2**	112.8
Cumulative impact of past year SLE			28.3	18.9	Cumulative impact of past year SLE			10.9	20.0
Total brain volume (mm³)			0.013***	0.0015	Total brain volume (mm³)			0.008***	0.0016

L. mPFC vol. (mm³)	Adj. R²	RSE	b	SE	R. mPFC vol. (mm³)	Adj. R²	RSE	b	SE
Model	0.559***	557.6			Model	0.539***	479.1
FEH			0.2	7.9	FEH			− 11.6	6.8
Sex (female)			159.9	173.6	Sex (female)			53.1	149.1
Age			− 102.9*	50.2	Age			− 11.6	43.1
Cumulative impact of past year SLE			4.8	8.9	Cumulative impact of past year SLE			5.7	7.7
Total brain volume (mm³)			0.006***	0.0007	Total brain volume (mm³)			0.005***	0.0006

L. amygdala vol. (mm³)	Adj. R²	RSE	b	SE	R. amygdala vol. (mm³)	Adj. R²	RSE	b	SE
Model	0.404***	139.2			Model	0.356***	166.2
FEH			5.2**	2.0	FEH			5.8*	2.3
Sex (female)			− 34.5	43.3	Sex (female)			− 34.3	51.7
Age			− 3.6	12.5	Age			− 5.1	15.0
Cumulative impact of past year SLE			3.5	2.2	Cumulative impact of past year SLE			0.7	2.7
Total brain volume (mm³)			0.001***	0.0002	Total brain volume (mm³)			0.001***	0.0002

P: BH-significant (bolded)
Four genomic ancestry multi-dimensional scaling measures were included in each model, but are not shown here
RSE relative standard error, adj adjusted, b estimate, SE standard error, L left, R right, hipp hippocampus, vol volume
***P < 0.001; **P < 0.01; *P < 0.05

ISSN: 1868-7083