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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood

Fig. 3

Conceptual model testing module eigengenes (MEs) as mediators of the hypothesized association between family emotional health (FEH) and variability in hemisphere-specific brain region volume (BRV). Arm A. FEH was used as a predictor of hemisphere-specific BRV, while including age, biological sex, four genomic ancestry MDS measures, past year SLEs, and total brain volume as covariates. Arm B. FEH was used as a predictor of ME value, while including past year SLEs as a covariate. The age, sex, and genomic ancestry effects on ME components were previously removed. Arm C. ME values were used as individual predictors of BRV, while including age, biological sex, four genomic ancestry MDS measures, past year SLEs, and total brain volume as covariates

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