DNA methylation in cord blood in association with prenatal depressive symptoms

Clinical Epigenetics

Table 2 Overview of the number of differentially methylated CpG sites in different group comparisons

		Whole				Girls				Boys
Group 1	Group 2	n1	n2	pa	pu	n1	n2	pa	pu	n1	n2	pa	pu
Healthy control	Prenatal depressive symptoms	194	165	0	49,385	98	77	0	43,762	96	88	0	35,603
History and prenatal depressive symptoms	Prenatal depressive symptoms only	147	32	0	37,873	65	18	0	43,919	82	14	38	39,150
History and prenatal depressive symptoms	Healthy control	147	194	0	44,372	65	98	0	37,458	82	96	0	35,522
Prenatal depressive symptoms only	Healthy control	32	194	0	45,043	18	98	0	47,277	14	96	6	39,941
Anxiety and prenatal depressive symptoms	Prenatal depressive symptoms only	95	70	0	56,366	41	36	0	46,103	54	34	0	44,805
Anxiety and prenatal depressive symptoms	Healthy control	95	194	2	44,230	41	98	0	39,519	54	96	0	36,549
Prenatal depressive symptoms only	Healthy control	70	194	0	62,013	36	98	0	50,096	34	96	0	41,260
Healthy control	Prenatal depressive symptoms without SSRI	194	149	0	48,338	98	71	0	41,955	96	78	0	34,973
Healthy control	Prenatal depressive symptoms with SSRI	194	13	14	44,881	98	4	109	48,451	96	9	14	49,785
Prenatal depressive symptoms without SSRI	Prenatal depressive symptoms with SSRI	149	13	14	41,708	71	4	131	40,940	78	9	12	50,239

pa = number of CpGs significant with p-value adjusted for multiple testing and for sample plate batch, sentrix position on the chip, granulocyte cell estimate, nucleated red blood cell estimate, CD8T-cell estimate, maternal age at partus, pre-pregnancy body mass index, maternal place of birth, parity, gestational age, delivery mode, and maternal education
pu = number of differentially methylated CpGs with an unadjusted significant p-value

ISSN: 1868-7083