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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Epigenetic evidence of an Ac/Dc axis by VPA and SAHA

Fig. 5

SAHA influences H3K19/14ac and H3K9me3 content on the promoters of NFκB pathway genes as identified by ChIP-Seq. a Differential enrichment was determined using MACS and visualised using SeqMonk. b Real-time PCR validation of changes in gene expression of NFκB signalling pathway-related genes after exposure to SAHA. Gene expression was analysed in three independent experiments before and after exposure to SAHA. Real-time PCR validation of c H3K9/14ac and d H3K9me3 by ChIP for NFκB signalling pathway genes in mock and SAHA-exposed cells. Yields were analysed with respect to input. ** = P < 0.01 *** = P < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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