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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Epigenetic evidence of an Ac/Dc axis by VPA and SAHA

Fig. 2

Genome-wide distribution of chromatin modifications shows significant changes in histone modification by VPA and SAHA. Distribution plots show the read count (log2 read abundance) compared with fold change (log2FC) of differential regions determined by edgeR, comparing VPA and SAHA stimulated against unstimulated human fibroblast cells (Bonferroni-adjusted P < 0.05). ChIP-seq regions subject to significant change are shown in red and non-significant change shown in blue for VPA- and SAHA-stimulated cells. ChIP-seq distribution plots are shown for VPA a H3K9/14ac, c H3K4me3 and e H3K9me3 and SAHA b H3K9/14ac, d H3K4me3 and f H3K9me3. All peaks considered significant by MACS (P < 10–4) are included. Higher scores represent stronger changes

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