From: A review of epigenetic changes in asthma: methylation and acetylation
Author and year | Subjects | Specimen | Status | Gene/region | Differentiation | References |
---|---|---|---|---|---|---|
Cosio et al. 2004 | Adults with atopic asthma | Alveolar macrophages and peripheral blood monocytes | Mild, moderate, and severe asthma in response to drugs that change HDAC and HAT activity | HDAC | Histone acetylation | [140] |
Pascual et al. 2011 | Adults with allergic asthma | PBMC | allergic subjects, aspirin-intolerant asthmatics, and healthy subjects | CYP26A1 | Hypermethylation | [134] |
Isidoro-GarcÃa et al. 2011 | Adults with allergic asthma | PBMC derived CD19 + B lymphocytes | Asthma severity | PTGDR | Hypomethylation | [137] |
Runyon et al. 2012 | Adult monozygotic twins | Peripheral whole blood and BALF | Childhood asthma discordancy | IFN-γ and FOXP3 | Hypermethylation | [136] |
Yang et al. 2013 | Adults | Peripheral blood leukocytes | Asthma severity | ADAM33 | Same methylation pattern | [139] |
Li et al. 2013 | Adults with allergic asthma | Peripheral blood T-cells | Severe eosinophilic asthma with glucocorticoid resistance | LAT | Histone hypoacetylation | [37] |
Gunawardhana et al. 2014 | Male and female adults with stable asthma | Peripheral blood CD14 + monocytes | eosinophilic asthma, paucigranulocytic asthma, and neutrophilic asthma | 223, 237, and 72 differentially methylated CpG loci | Hypermethylation | [135] |
Xiao et al. 2015 | Children | Nasal epithelial cells | Corticosteroid treatment response | Vanin-1 | DNA methylation | [141] |
Zhang et al. 2017 | Children | Nasal epithelial cells | Steroid treatment response | OTX2 and LDHC | DNA methylation | [129] |
Yang et al. 2017 | Inner-city children | Nasal epithelial cells | Persistent atopic asthma | 186 genes | DNA methylation | [146] |
Xu et al. 2018 | Children | Nasal cells, cord blood, whole blood, peripheral blood | Allergic asthma | 14 CpG Sites | Hypomethylation | [144] |
Reese et al. 2019 | Newborns and children | Whole blood and nasal respiratory epithelium cells and eosinophils | Asthma diagnosis in newborns and children | 179 CpGs with 36 regions in children and 9 CpGs with 35 regions in newborns | DNA methylation | [145] |
Shi et al. 2020 | Children | Nasal epithelial cells | Childhood atopic asthma | TNF and HLA-DBA1 | DNA methylation | [147] |
Vermeulen et al. 2020 | Adults | Ciliated epithelial cells, basal cells, smooth muscle cells, fibroblasts, neutrophils, and T-cells | Persistence and remission in asthma and in different cell types | 4 differentially methylated CpG sites and 42 regions | DNA methylation | (133) |