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Table 1 Summary of the research works about the DNA methylation role in asthma-related genes and pathways

From: A review of epigenetic changes in asthma: methylation and acetylation

Author and year

Subjects

Specimen

Genes/regions

Phenotype

References

Kwon et al. 2008

Adults

Venous blood, cultured CD4 + 

IL-4 and IFN-γ

Bronchial asthma

[33]

Breton et al. 2011

Children

Buccal cells

NOS1, NOS2A, NOS3, ARG1, and ARG2

Childhood asthma

[23]

Brand et al. 2012

Female BALB/c mice and BALB/\({c}^{\mathrm{scid}}\) mice

Blood

CNS1 and IFN-γ

Asthma

[32]

Baccarelli et al. 2012

Children

Nasal cell

IL-6 and iNOS

Childhood asthma

[24]

Verma et al. 2013

Balb/c mice

lung, trachea tissues and BALF cells and Whole blood

DNMT1, Socs3, STAT3, IFN-y, IL-4, IL-5 and IL-6

Asthma

[34]

Gagné-Ouellet et al. 2015

Adult and Children

Whole blood

IL1R1 and IL1R2

Asthma and atopy

[41]

Larouche et al. 2018

Adults

Bronchial epithelial cell line

CCL26 and IL-33

Asthma

[42]

Forno et al. 2019

Children

Nasal cells

30 CpG regions

Atopy and atopic asthma

[36]