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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Differential methylation EPIC analysis discloses cisplatin-resistance related hypermethylation and tumor-specific heterogeneity within matched primary and metastatic testicular germ cell tumor patient tissue samples

Fig. 3

Scatterplots of the mean beta values (a, c, e, g) and volcano plots of each pairwise comparison (b, d, f, h) related to differential methylation across histologies, at the promoter level. a, b Non-seminoma–seminoma; c, d Embryonal carcinoma–seminoma; e, f Yolk sac tumor/teratoma–Seminoma; g, h Yolk sac tumor/teratoma–embryonal carcinoma. In the scatterplots, the transparency corresponds to point density. Blue points represent differentially methylated sites (according to the combined rank criteria, see Methods). Red dots represent the 1000 best ranking sites. In the volcano plots, dots are colored according to combined rank, and the yy axis represents the combined p values. EC embryonal carcinoma, SE seminoma, TE teratoma, YST yolk sac tumor

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