Fig. 2

Inhibition of EZH2 improved the effect of blocking immune checkpoint. (1) In tumor cell, high level EZH2 can inhibit CD274, the transcription factor of PD-L1. Tumor cell with low expression of PD-L1 showed resistance to anti-PD-L1 therapy, which can recover the sensitivity after inhibition EZH2. (2) In iTregs, EZH2 overexpression enhances its suppression to CD8⁺T cells that cannot kill tumor cells. Addition of EZH2 inhibitors can restore CD8⁺T cells activity to enhance antitumor ability. 3) EZH2 overexpression in tumor cells inhibits the expression of MHC I, and influences the efficacy of anti-PD-1 treatment. Treatment with EZH2 inhibitor improves the efficacy of anti-PD-1 therapy.