Symbol | Known expression level in cardiomyocytes* | Protein level in the plasma/serum‡ | Rank in the O2PLS analysis | Transcriptome change (log2FC) | Proteome change (log2FC) | Histone acetylome change in the matched direction (50 Kb of TSS) | Transcriptome change in diseased versus control cardiomyocytesϯ log2(FC) |
---|---|---|---|---|---|---|---|
AASS | Medium | Detected | 1046 |  − 1.279808444 |  − 0.773247332 | Yes |  − 0.414920406 |
ABHD11 | Medium | Detected | 669 | 1.137180651 | 0.640971138 | – | – |
ACTN2 | High | Detected | 1597 | 0.570095367 | 0.184641682 | – | – |
ADH1B | Low | Detected | 1281 |  − 1.081956134 |  − 0.880289941 | – | – |
ARHGAP1 | Medium | Detected | 1512 | 1.763584 | 0.597291165 | Yes | – |
ASPN | Not detected | Detected | 454 | 2.204317 | 1.77725136 | Yes | – |
ATP2A2 | High | Detected | 728 |  − 1.466783433 |  − 0.353968239 | – | – |
BGN | Medium | Detected | 1012 | 1.832538 | 1.533815477 | – | 0.588280947 |
C6 | Not detected | Detected | 130 |  − 1.776237721 |  − 0.695516121 | – | – |
CA3 | Not detected | Detected | 43 | 4.518344 | 1.686864533 | – | – |
CHCHD6 | Medium | Not detected | 910 | 2.003514 | 0.778880421 | – | – |
CHDH | Low | Not detected | 98 |  − 2.209806815 |  − 1.442995937 | Yes | – |
CLGN | Not detected | Not detected | 1751 |  − 1.088152172 |  − 0.808838009 | Yes | – |
DDAH1 | Not detected | Detected | 452 | 1.764206 | 1.115473264 | Yes | – |
EFHD1 | Not detected | Not detected | 682 | 1.865517 | 1.264459654 | Yes | 0.318203232 |
FGF12 | No data | Not detected | 62 |  − 2.353022973 |  − 1.079274106 | Yes |  − 0.30374396 |
FHL2 | High | Not detected | 440 |  − 1.255001122 |  − 0.411782639 | – | – |
FMOD | No data | Detected | 395 | 2.594323 | 1.414783229 | Yes | – |
FSCN1 | Not detected | Detected | 1276 | 1.759951 | 0.971207984 | Yes | 0.456046007 |
GATM | Not detected | Detected | 277 | 1.545734889 | 1.002695568 | Yes | – |
GPD1 | Medium | Detected | 1708 |  − 1.687472289 |  − 1.343895776 | Yes |  − 0.410181446 |
GPD1L | No data | Not detected | 1342 |  − 1.066784553 |  − 0.526757351 | – | – |
HSPA2 | Not detected | Detected | 171 | 3.490234 | 2.652261545 | Yes | – |
HSPB6 | High | Detected | 647 | 2.253803 | 0.392977171 | – |  − 3.170003763 |
LDHA | Not detected | Detected | 974 |  − 1.219034333 |  − 0.474108409 | Yes | – |
LTBP2 | Not detected | Detected | 829 | 2.1279 | 2.317830122 | Yes | – |
LUM | Not detected | Detected | 217 | 2.135187 | 0.959297891 | – | 0.512857369 |
MAP4 | Medium | Detected | 717 | 1.851811 | 1.003525943 | Yes |  − 0.223635511 |
MCAM | Low | Detected | 1338 | 1.653115 | 1.104716402 | Yes |  − 0.264831197 |
MFAP2 | Not detected | Not detected | 1303 | 1.84358 | 0.70531399 | Yes |  − 0.357062335 |
MYH6 | High | Detected | 40 |  − 2.919038787 |  − 1.009056575 | – | – |
MYL12A | Medium | Detected | 64 | 2.419604 | 0.578322489 | – |  − 0.14329672 |
MYLK3 | High | Not detected | 1904 |  − 1.007764366 |  − 0.747812735 | – | 0.127033902 |
NES | Medium | Detected | 641 | 1.806419 | 1.936943877 | – | – |
NPPA | Medium | Detected | 13 | 1.549472808 | 0.747781872 | Yes | 0.542363796 |
NUDT4 | High | Not detected | 1531 |  − 1.093022558 |  − 0.695436878 | – | 0.207067638 |
PDK4 | High | Not detected | 1724 |  − 1.07459529 |  − 0.607585372 | Yes | – |
RAB24 | No data | Not detected | 1085 | 2.211788 | 1.041018278 | – | – |
RRAS | High | Detected | 1642 | 1.788982 | 0.447281909 | – | – |
S100A6 | Not detected | Detected | 1486 | 1.859224 | 0.794548978 | – | – |
SAA1 | No data | Detected | 63 |  − 1.173021107 |  − 2.740052623 | – | – |
SERPINE2 | No data | Detected | 338 | 1.002427623 | 0.652055032 | – | 0.714236168 |
SGCG | High | Not detected | 1805 | 0.707480434 | 0.430185184 | Yes | – |
SLC25A5 | High | Detected | 1634 | 1.811682 | 0.613247381 | – | – |
SNCA | Not detected | Detected | 274 | 2.629958 | 1.02410125 | – | – |
SORBS2 | No data | Detected | 1991 | 1.475585 | 0.484980733 | Yes |  − 0.241151423 |
STMN1 | Not detected | Detected | 1211 | 0.77170211 | 0.807423435 | – | – |
SYNPO2L | High | Not detected | 483 | 2.306538 | 1.028059491 | Yes | – |
TANGO2 | Low | Detected | 1086 | 1.981163 | 0.733156318 | – | – |
THBS4 | Low | Detected | 618 | 2.323482 | 2.106545221 | – | – |
TPM3 | Medium | Detected | 981 | 2.116673 | 1.224815654 | – | 0.36243013 |
TPPP | Not detected | Not detected | 1374 |  − 0.898226805 |  − 0.830942802 | Yes | – |
UCHL1 | Not detected | Detected | 44 | 5.052289 | 0.933127805 | – | – |