Skip to main content

Table 1 Promising candidates showing the same changing direction in HCM versus control hearts at multi-omics levels

From: Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Symbol

Known expression level in cardiomyocytes*

Protein level in the plasma/serum‡

Rank in the O2PLS analysis

Transcriptome change (log2FC)

Proteome change (log2FC)

Histone acetylome change in the matched direction (50 Kb of TSS)

Transcriptome change in diseased versus control cardiomyocytesϯ log2(FC)

AASS

Medium

Detected

1046

 − 1.279808444

 − 0.773247332

Yes

 − 0.414920406

ABHD11

Medium

Detected

669

1.137180651

0.640971138

–

–

ACTN2

High

Detected

1597

0.570095367

0.184641682

–

–

ADH1B

Low

Detected

1281

 − 1.081956134

 − 0.880289941

–

–

ARHGAP1

Medium

Detected

1512

1.763584

0.597291165

Yes

–

ASPN

Not detected

Detected

454

2.204317

1.77725136

Yes

–

ATP2A2

High

Detected

728

 − 1.466783433

 − 0.353968239

–

–

BGN

Medium

Detected

1012

1.832538

1.533815477

–

0.588280947

C6

Not detected

Detected

130

 − 1.776237721

 − 0.695516121

–

–

CA3

Not detected

Detected

43

4.518344

1.686864533

–

–

CHCHD6

Medium

Not detected

910

2.003514

0.778880421

–

–

CHDH

Low

Not detected

98

 − 2.209806815

 − 1.442995937

Yes

–

CLGN

Not detected

Not detected

1751

 − 1.088152172

 − 0.808838009

Yes

–

DDAH1

Not detected

Detected

452

1.764206

1.115473264

Yes

–

EFHD1

Not detected

Not detected

682

1.865517

1.264459654

Yes

0.318203232

FGF12

No data

Not detected

62

 − 2.353022973

 − 1.079274106

Yes

 − 0.30374396

FHL2

High

Not detected

440

 − 1.255001122

 − 0.411782639

–

–

FMOD

No data

Detected

395

2.594323

1.414783229

Yes

–

FSCN1

Not detected

Detected

1276

1.759951

0.971207984

Yes

0.456046007

GATM

Not detected

Detected

277

1.545734889

1.002695568

Yes

–

GPD1

Medium

Detected

1708

 − 1.687472289

 − 1.343895776

Yes

 − 0.410181446

GPD1L

No data

Not detected

1342

 − 1.066784553

 − 0.526757351

–

–

HSPA2

Not detected

Detected

171

3.490234

2.652261545

Yes

–

HSPB6

High

Detected

647

2.253803

0.392977171

–

 − 3.170003763

LDHA

Not detected

Detected

974

 − 1.219034333

 − 0.474108409

Yes

–

LTBP2

Not detected

Detected

829

2.1279

2.317830122

Yes

–

LUM

Not detected

Detected

217

2.135187

0.959297891

–

0.512857369

MAP4

Medium

Detected

717

1.851811

1.003525943

Yes

 − 0.223635511

MCAM

Low

Detected

1338

1.653115

1.104716402

Yes

 − 0.264831197

MFAP2

Not detected

Not detected

1303

1.84358

0.70531399

Yes

 − 0.357062335

MYH6

High

Detected

40

 − 2.919038787

 − 1.009056575

–

–

MYL12A

Medium

Detected

64

2.419604

0.578322489

–

 − 0.14329672

MYLK3

High

Not detected

1904

 − 1.007764366

 − 0.747812735

–

0.127033902

NES

Medium

Detected

641

1.806419

1.936943877

–

–

NPPA

Medium

Detected

13

1.549472808

0.747781872

Yes

0.542363796

NUDT4

High

Not detected

1531

 − 1.093022558

 − 0.695436878

–

0.207067638

PDK4

High

Not detected

1724

 − 1.07459529

 − 0.607585372

Yes

–

RAB24

No data

Not detected

1085

2.211788

1.041018278

–

–

RRAS

High

Detected

1642

1.788982

0.447281909

–

–

S100A6

Not detected

Detected

1486

1.859224

0.794548978

–

–

SAA1

No data

Detected

63

 − 1.173021107

 − 2.740052623

–

–

SERPINE2

No data

Detected

338

1.002427623

0.652055032

–

0.714236168

SGCG

High

Not detected

1805

0.707480434

0.430185184

Yes

–

SLC25A5

High

Detected

1634

1.811682

0.613247381

–

–

SNCA

Not detected

Detected

274

2.629958

1.02410125

–

–

SORBS2

No data

Detected

1991

1.475585

0.484980733

Yes

 − 0.241151423

STMN1

Not detected

Detected

1211

0.77170211

0.807423435

–

–

SYNPO2L

High

Not detected

483

2.306538

1.028059491

Yes

–

TANGO2

Low

Detected

1086

1.981163

0.733156318

–

–

THBS4

Low

Detected

618

2.323482

2.106545221

–

–

TPM3

Medium

Detected

981

2.116673

1.224815654

–

0.36243013

TPPP

Not detected

Not detected

1374

 − 0.898226805

 − 0.830942802

Yes

–

UCHL1

Not detected

Detected

44

5.052289

0.933127805

–

–

  1. * The known expression level of each candidate in cardiomyocyte is collected from the Human Protein Atlas (https://www.proteinatlas.org/)
  2. ‡The detectable protein level of each candidate in plasma and serum is collected from the Human Plasma Proteome Project Data Central (http://www.peptideatlas.org/hupo/hppp/)
  3. ϯDifferentially expressed genes between programmed cardiomyocytes with and without mutated MYBPC3 from a published study were used with a threshold of P value below 0.05 (GSE140965)
  4. FC fold change, TSS transcription start site, – not matching