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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Fig. 3

a An overview of protein–protein interactions of up-regulated proteins in HCM versus control hearts. Each node represents an individual protein. Nodes highlighted in red are involved in the top enriched pathway in extracellular matrix organization (ECM). Nodes highlighted in blue are involved in the top enriched pathway in muscle contraction. b An overview of protein–protein interactions of down-regulated proteins in HCM versus control hearts. Each node represents an individual protein. Nodes highlighted in green are involved in the top enriched pathway in metabolism. c Transcription factors enriched in differentially acetylated chromatin regions and their corresponding P values (Fisher test) are shown on the left, and their mRNA expression levels among all samples are shown in the heatmap on the right. RPKM: reads per kilobase million. d Western blot data showing the protein levels of KLF15 and RXRA were comparable between HCM and control hearts. e A schematic overview showing all analysis steps in histone acetylome, transcriptome, and proteome data used in this study

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