Table 4 Biological pathways/processes on genes with CpGs showing consistent interaction effects between IoW and ALSPAC
From: Pre-adolescence DNA methylation is associated with BMI status change from pre- to post-adolescence
Gene | Source | p values* | |
|---|---|---|---|
Pathways | Pathways | ||
P2RX4 | REACTOME | Elevation of cytosolic Ca2 + levels | 9.521 × 10–3 |
Platelet calcium homeostasis | 1.730 × 10–2 | ||
WDR19 | Intraflagellar transport | 2.283 × 10–2 | |
FLNB | Antiviral mechanism by IFN-stimulated genes | 4.251 × 10–2 | |
ISG15 antiviral mechanism | 4.251 × 10–2 | ||
FLNB | KEGG | Salmonella infection | 4.737 × 10–2 |
GO biological processes | |||
WDR19 | Myotome development | 1.588 × 10–3 | |
Ciliary receptor clustering involved in smoothened signaling pathway | 1.588 × 10–3 | ||
PCDHGB5, PCDHGC3, PCDHGA6, RADIL | Cell adhesion | 1.718 × 10–3 | |
P2RX4 | Positive regulation of microglial cell migration | 1.984 × 10–3 | |
Sensory perception of touch | 2.381 × 10–3 | ||
Regulation of microglial cell migration | 2.777 × 10–3 | ||
P2RX4, LYNX1 | Chemical synaptic transmission, postsynaptic | 2.589 × 10–3 | |
FLNB | Cytoskeletal anchoring at plasma membrane | 4.756 × 10–3 |