Pre-adolescence DNA methylation is associated with BMI status change from pre- to post-adolescence

Wang, Jiajing; Zhang, Hongmei; Rezwan, Faisal I.; Relton, Caroline; Arshad, S. Hasan; Holloway, John W.

doi:10.1186/s13148-021-01042-4

Clinical Epigenetics

Table 3 Gender specificity in the effects of DNAm on BMI status transition during adolescence

From: Pre-adolescence DNA methylation is associated with BMI status change from pre- to post-adolescence

Name	10–18 years (IoW)					7–15 years (ALSPAC)
	Main effects (DNAm)		Interaction effects (DNAm × gender)			Main effects (DNAm)		Interaction effects (DNAm × gender)		Gene name and Gene’s location
	Est.*	p_raw*	Est	p_raw	p_FDR*	Est	p_raw	Est	p_raw	Name	Location
	Persistence of OwO*
cg15648188	2.86	0.02	−6.72	2.89 × 10^–4	0.03	0.63	0.24	0.08	0.91	BC023516	Body
cg04131949	−2.22	0.03	5.83	1.60 × 10^–3	0.04	0.28	0.46	−0.89	0.12	RAB11FIP3	Body
cg25806347	2.16	0.24	−11.05	2.43 × 10^–3	0.04	−0.15	0.77	−0.16	0.82	SIX2	Body
cg24982697	−5.07	4.89 × 10^–4	5.46	2.56 × 10^–3	0.04	0.29	0.32	−0.26	0.54	ATP11A	Body
cg02746620	−8.06	6.44 × 10^–4	8.89	8.21 × 10^–4	0.04	0.20	0.71	0.01	0.99	SLIT3	Body
cg13585675	−6.21	0.002	7.24	0.002	0.04	0.17	0.66	−0.35	0.56	NPTX2	Body
cg16460342	1.09	0.29	−5.62	2.62 × 10^–3	0.04	−0.22	0.60	0.03	0.96	P2RX4	Body
cg00283283	−11.47	0.001	12.71	3.61 × 10^–3	0.04	−0.35	0.53	0.27	0.75	*PCDHGB5;PCDHGC3;PCDHGA6*	*3′UTR;3′UTR;3′UTR;3′UTR;3′U*
cg00928795	−6.33	0.01	9.11	3.80 × 10^–3	0.04	−0.33	0.58	0.33	0.71	*AK057218*	*Body*
cg02380833	3.49	0.02	−5.13	5.00 × 10^–3	0.05	−0.65	0.16	0.75	0.25	PTPRO	TSS1500
	Transition from Normal to OwO
cg01959050	−6.12	6.76 × 10^–4	10.21	6.69 × 10^–5	0.007	0.15	0.85	−0.23	0.81	DKFZP451C023	Body
cg15511327	3.06	0.04	−9.24	1.83 × 10^–4	0.01	0.30	0.58	−0.26	0.70	*LYNX1*	*1stExon;5′UTR;TSS1500;1stEx*
cg07719077	−2.35	0.17	8.01	5.56 × 10^–3	0.04	−0.26	0.66	0.04	0.96	*KIAA1211*	*Body*
cg14478163	7.24	0.002	−8.08	2.35 × 10^–3	0.04	−0.59	0.33	0.25	0.74	ANKRD34B	TSS200
cg21862373	5.87	0.009	−7.48	5.07 × 10^–3	0.04	−1.41	0.09	1.51	0.12	SNHG9;RPS2;SNORA78	TSS1500;5′UTR;TSS1500
cg14610958	−2.75	0.007	3.86	4.38 × 10^–3	0.04	0.03	0.97	−0.60	0.43	ANGEL2	TSS1500
cg00331210	−8.60	0.009	12.21	1.96 × 10^–3	0.04	−0.24	0.74	0.78	0.37	*NARFL*	*3′UTR*
cg22059735	−1.13	0.44	6.15	4.75 × 10^–4	0.04	–	–	–	–	AK057493;BC043255;BC035866	Body
cg07378760	−0.72	0.08	2.36	2.63 × 10^–3	0.04	−0.77	0.65	0.74	0.69	*FLNB*	*TSS200*
cg24158437	−7.02	0.002	7.23	3.82 × 10^–3	0.04	1.07	0.10	−0.99	0.20	KLHL32	Body
cg13629132	−3.71	0.009	4.86	5.26 × 10^–3	0.04	0.62	0.20	−0.88	0.11	AX747623	Body
cg08402439	−3.78	0.03	7.81	1.60 × 10^–3	0.04	0.25	0.57	−0.61	0.27	AGA;NEIL3	Body
cg04120329	3.70	6.73 × 10^–4	−3.85	3.89 × 10^–3	0.04	0.67	0.20	−0.88	0.16	*PRAP1*	*TSS1500*
cg11878331	0.86	0.07	−2.43	4.94 × 10^–3	0.04	−0.32	0.71	0.34	0.76	BC048982	Body
cg23244169	0.45	0.68	−4.71	6.23 × 10^–3	0.04	0.43	0.45	−1.18	0.09	*C17orf45*	*Body*
cg00842549	5.83	6.32 × 10^–4	−5.84	7.76 × 10^–3	0.05	0.18	0.74	0.32	0.63	HOXB3	TSS200
cg15125798	−2.41	0.03	4.52	2.30 × 10^–3	0.02	−0.52	0.32	0.25	0.68	–	–
	Transition from OwO to Normal
cg11249998	6.64	0.003	−9.95	3.83 × 10^–4	0.01	−0.04	0.96	0.10	0.93	NME2;NME2;NME1-NME2;NME	5′UTR;TSS1500;Body;1stExon;
cg15708019	2.66	0.003	−3.81	2.42 × 10^–4	0.01	0.09	0.95	−0.69	0.61	*WDR19*	*TSS200*
cg14260083	-2.65	0.009	5.11	4.13 × 10^–4	0.01	-0.19	0.58	1.22	0.04	*RADIL*	*Body*

In total, 29 CpGs were identified in the IoW cohort and tested in the ALSPAC cohort. Female is the reference group. Results in bold font denote that the estimated regression coefficients (both main effects and interaction effects) are in the same directions between the two cohorts
^*OwO means Overweight/Obese. Est.: Estimate of regression coefficients. p_raw: raw p value. p_FDR: FDR-adjusted p value.

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