Table 4 Mendelian randomization results of lung cancer using gene expression data as the exposure
Outcome | Exposure | Method | Beta | se | P value | Tissue origin |
|---|---|---|---|---|---|---|
Lung cancer | CHRNA5 | Inverse variance weighted | − 1.50 | 0.23 | 6.80E − 11 | FHS Whole blood |
Squamous cell lung cancer | CHRNA5 | Inverse variance weighted | − 1.23 | 0.31 | 9.05E − 05 | FHS Whole blood |
Lung adenocarcinoma | CHRNA5 | Inverse variance weighted | − 1.58 | 0.42 | 1.48E − 04 | FHS Whole blood |
Lung cancer | CHRNA5 | Wald ratio | − 0.22 | 0.03 | 9.24E − 13 | GTEx lung |
Lung adenocarcinoma | CHRNA5 | Wald ratio | − 0.23 | 0.05 | 5.13E − 07 | GTEx lung |
Squamous cell lung cancer | CHRNA5 | Wald ratio | − 0.17 | 0.05 | 3.86E − 04 | GTEx lung |