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Table 4 Mendelian randomization results of lung cancer using gene expression data as the exposure

From: Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases

Outcome Exposure Method Beta se P value Tissue origin
Lung cancer CHRNA5 Inverse variance weighted  − 1.50 0.23 6.80E − 11 FHS Whole blood
Squamous cell lung cancer CHRNA5 Inverse variance weighted  − 1.23 0.31 9.05E − 05 FHS Whole blood
Lung adenocarcinoma CHRNA5 Inverse variance weighted  − 1.58 0.42 1.48E − 04 FHS Whole blood
Lung cancer CHRNA5 Wald ratio  − 0.22 0.03 9.24E − 13 GTEx lung
Lung adenocarcinoma CHRNA5 Wald ratio  − 0.23 0.05 5.13E − 07 GTEx lung
Squamous cell lung cancer CHRNA5 Wald ratio  − 0.17 0.05 3.86E − 04 GTEx lung