Table 3 Mendelian randomization results of lung cancer as the outcome using DNA methylation as the exposure
Outcome | Exposure | Beta | se | P value | Tissue origin |
|---|---|---|---|---|---|
Lung cancer | cg03234777 |  − 3.81 | 1.24 | 2.17E − 03 | FHS Whole blood |
Lung adenocarcinoma | cg03234777 |  − 4.96 | 1.95 | 1.09E − 02 | FHS Whole blood |
Squamous cell lung cancer | cg03234777 |  − 1.32 | 1.83 | 4.70E − 01 | FHS Whole blood |
Lung cancer | cg19696491 |  − 5.28 | 0.77 | 5.05E − 12 | FHS Whole blood |
Lung adenocarcinoma | cg19696491 |  − 5.65 | 1.16 | 1.18E − 06 | FHS Whole blood |
Squamous cell lung cancer | cg19696491 |  − 3.93 | 1.21 | 1.11E − 03 | FHS Whole blood |
Lung cancer | cg22563815 |  − 4.64 | 0.67 | 5.05E − 12 | FHS Whole blood |
Lung adenocarcinoma | cg22563815 |  − 4.96 | 1.02 | 1.18E − 06 | FHS Whole blood |
Squamous cell lung cancer | cg22563815 |  − 3.45 | 1.06 | 1.11E − 03 | FHS Whole blood |
Illnesses of father: lung cancer | cg22563815 |  − 0.081 | 0.031 | 8.28E − 03 | FHS Whole blood |
Illnesses of father: lung cancer | cg19696491 |  − 0.092 | 0.035 | 8.47E − 03 | FHS Whole blood |
Cancer code self-reported: lung cancer | cg03234777 |  − 0.010 | 0.005 | 3.43E − 02 | FHS Whole blood |
Lung adenocarcinoma | cg22563815 |  − 1.569 | 0.308 | 3.60E − 07 | Lung tissue |
Lung cancer | cg22563815 |  − 1.456 | 0.203 | 7.04E − 13 | Lung tissue |
Squamous cell lung cancer | cg22563815 |  − 1.127 | 0.319 | 4.04E − 04 | Lung tissue |
Lung adenocarcinoma | cg19696491 |  − 2.051 | 0.416 | 8.35E − 07 | Lung tissue |
Lung cancer | cg19696491 |  − 1.929 | 0.274 | 1.82E − 12 | Lung tissue |
Squamous cell lung cancer | cg19696491 |  − 1.489 | 0.429 | 5.25E − 04 | Lung tissue |