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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Genome-wide analysis of DNA methylation in Hirschsprung enteric precursor cells: unraveling the epigenetic landscape of enteric nervous system development

Fig. 3

Statistically significant enriched biological processes of DMRs genes in HSCR patients. a Histogram that shows the Gene enrichment analysis of genes with DMRs in HSCR patients versus controls. b Enrichment network where each term is represented by a circle node, where its size is proportional to the number of input genes fall into that term, and its color represents its cluster identity (i.e., nodes of the same color belong to the same cluster). Terms with a similarity score > 0.3 are linked by an edge (the thickness of the edge represents the similarity score). The network is visualized with Cytoscape (v3.1.2) with “force-directed” layout and with edge bundled for clarity. Gene list included into the main and largest network as well as those genes included into the embryonic morphogenesis biological process were included into a list of promising candidates according to their biological processes

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Clinical Epigenetics

ISSN: 1868-7083

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