Fig. 2

The whole genome DNA methylation landscape of HSCR patients. a, b Distribution of DMRs throughout each genomic region and across gene elements, respectively. c Distribution of hypermethylated and hypomethylated DMRs in each genomic region. d DNA methylation level by annotation type throughout each chromosome. The red dashed line represents an unaltered methylation state (ß = 0). Negative values of ß represent hypomethylated DMRs, whereas positive values of ß represent hypermethylated DMRs. e DNA methylation level by the distance of the centromere. f Distribution of DMRs according to chromosomes