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Table 2 Multivariate models for the assessment of mAge deviation with adiposity and glycemic markers

From: Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial

  Model 1 Model 2 Model 3
β p value β p value β p value
Weight, kg 0.05 0.62
BMI, kg/m2 0.09 0.35 * * * *
WC, cm 0.14 0.13 * * * *
VAT, cm2 0.15 0.12 0.14 0.14 0.18 0.11
DSAT, cm2 0.07 0.48 0.06 0.63 0.06 0.63
SSAT, cm2 0.04 0.97 − 0.05 0.73 − 0.05 0.74
IHF, % 0.3 0.02 0.23 0.02 0.23 0.02
Fasting glucose, mg/dL 0.16 0.08 0.16 0.08 0.18 0.07
HOMA IR 0.15 0.12 0.14 0.16 0.15 0.15
HbA1c, % 0.06 0.49 0.07 0.48 0.07 0.48
  1. *Cannot be tested in a multivariate model due to collinearity of weight with WC/BMI. BMI body mass index, DSAT deep subcutaneous adipose tissue, HbA1c hemoglobin A1c, HOMA IR homeostatic model assessment of insulin resistance, IHF intrahepatic fat, SSAT superficial subcutaneous adipose tissue, VAT visceral adipose tissue, WC waist circumference. Significant associations (p < 0.05) are represented in bold. Non-significant associations with p < 0.1 are represented in italics
  2. Model 1: Standardized residuals—adjusted for sex
  3. Model 2: Standardized residuals—adjusted for sex and weight
  4. Model 3: Standardized residuals—adjusted for sex, weight and age