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Table 1 Baseline characteristics of the CENTRAL participants across sex-specific tertiles of mAge deviation

From: Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial

  Entire
n = 120
Low
tertile
n = 40
Intermediate tertile
n = 41
High tertile
n = 39
p between tertilesa p between extreme tertilesb
Age, years 48.6 ± 9.3 45.1 ± 10.2 50.7 ± 9.0 47.3 ± 8.4 0.19 0.92
mAge, years 60.3 ± 7.5 56.5 ± 7.5 62.2 ± 6.9 62.3 ± 6.8 2.6 × 10–4 0.001
Weight, kg 90.3 ± 11.4 88.3 ± 9.5 89.3 ± 12.9 92.9 ± 11.5 0.17 0.06
BMI, kg/m2 30.2 ± 3.3 29.8 ± 2.6 29.8 ± 3.4 30.9 ± 3.9 0.44 0.26
WC, cm 106.7 ± 8.1 105.2 ± 6.8 105.6 ± 8.6 109.4 ± 8.3 0.03 0.008
VAT, cm2 176.2 ± 61.2 166.3 ± 50.4 166.6 ± 59.8 196.4 ± 69.0 0.07 0.04
VAT proportion, % 34.3 ± 10.5 33.8 ± 10.7 33.5 ± 9.7 35.8 ± 11.2 0.59 0.44
DSAT, cm2 210.9 ± 70.0 204.3 ± 64.7 210.0 ± 78.4 218.6 ± 66.9 0.70 0.42
DSAT proportion, % 40.0 ± 6.1 39.8 ± 6.1 40.1 ± 5.8 39.4 ± 6.3 0.57 0.79
SSAT, cm2 134.9 ± 56.5 136.3 ± 55.6 130.0 ± 51.5 138.5 ± 63.2 0.79 0.87
SSAT proportion, % 25.6 ± 7.1 26.4 ± 7.3 25.7 ± 7.3 24.8 ± 6.9 0.63 0.33
IHFc, % 10.71 ± 10.6 8.3 ± 8.0 9.3 ± 9.8 14.5 ± 12.8 0.03 0.02
Fasting glucose, mg/dL 106.5 ± 16.2 100.8 ± 10.3 110.1 ± 18.9 108.4 ± 16.9 0.02 0.01
HOMA IRd 4.8 ± 3.5 3.9 ± 2.1 4.7 ± 3.5 5.9 ± 4.3 0.08 0.03
HbA1c, % 5.6 ± 0.5 5.5 ± 0.4 5.7 ± 0.5 5.6 ± 0.5 0.29 0.47
  1. Data are mean ± SD. aANOVA or Kruskal Wallis. bT-test or Mann–Whitney. cn = 119. dn = 114. Lowest tertile: men: ≤ − 0.44; women ≤ − 0.77; intermediate tertile: men: − 0.43 to 0.46, women: − 0.76 to 0.55; Highest tertile: men: 0.47+, women: 0.56+. Significant associations (p < 0.05) are represented in bold. Non-significant associations with p < 0.1 are represented in italics
  2. BMI body mass index, DSAT deep subcutaneous adipose tissue, HbA1c hemoglobin A1c, HOMA IR homeostatic model assessment of insulin resistance, IHF intrahepatic fat, SSAT superficial subcutaneous adipose tissue, VAT visceral adipose tissue, WC waist circumference