Fig. 3
From: Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells
Combination of MS023 with low concentrations of BMN-673 results in synthetic lethality of A549 lung adenocarcinoma cells. a Schematic for generating cell viability curves using the MTT assay. b Cell viability curves from A549 cells treated with a range of BMN-673 (0.3–60 nM) alone (blue line), or in combination with 0.2, 1, or 2 μM MS023 (red line) (n = 3). c The open-source R package SynergyFinder was used to visualize the dose–response of the combination of BMN-673 and MS023 in A549 cells and to calculate Bliss synergy scores. The Bliss synergy score is presented on the z-axis of the Bliss graph and is used to determine concentrations at which synergy occurs. Highest Bliss synergy score is highlighted in the graph