Skip to main content

Table 6 C-statistics evaluating the predictive performance of GrimAA on incident CVD in GENOA African Americans

From: Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans

Model C-statistic 95% CI
N = 945
Base model (age + sex) 0.595 0.525–0.664
Age + sex + GrimAA 0.643 0.576–0.709
Age + sex + FRS 0.687 0.624–0.749
Age + sex + FRS + GrimAA 0.698 0.637–0.759
N = 988
Base model (age + sex) 0.588 0.521–0.656
Age + sex + GrimAA 0.636 0.571–0.701
Age + sex + ASCVD 0.670 0.606–0.728
Age + sex + ASCVD + GrimAA 0.685 0.625–0.746
  1. The C statistics associated with a set of nested models for time to CVD events are shown. All models are adjusted for familial relatedness
  2. Cardiovascular disease (CVD) was defined as self-reported myocardial infarction, coronary artery revascularization, cerebrovascular events, or surgical carotid artery revascularization
  3. CVD, cardiovascular disease; FRS, Framingham risk score; ASCVD, atherosclerotic cardiovascular disease