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Table 4 Incident CVD hazard ratios for epigenetic age acceleration in GENOA African Americans

From: Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans

Epigenetic age acceleration (predictor) HR (95% CI) P value
IEAA 0.97 (0.93–1.02) 0.300
EEAA 1.04 (1.00–1.08) 0.057
PhenoAA 1.00 (0.97–1.04) 0.810
GrimAA 1.09 (1.04–1.15) 4.20 × 10–4
  1. Models are adjusted for age, sex and familial relatedness
  2. CVD, cardiovascular disease; HR, hazard ratio; IEAA, intrinsic epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration
  3. Hazard ratios correspond to the risk of a CVD event associated with a 1-year increase in the epigenetic age acceleration measure
  4. Cardiovascular disease (CVD) was defined as self-reported myocardial infarction, coronary artery revascularization, cerebrovascular events, or surgical carotid artery revascularization
  5. Associations significant at P < 0.05 are shown in bold