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Table 2 Association between epigenetic age acceleration and cardiometabolic risk factors in GENOA African Americans

From: Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans

Cardiometabolic risk factor (outcome) IEAA EEAA PhenoAA GrimAA
β 95% CI P value β 95% CI P value β 95% CI P value β 95% CI P value
SBP 0.37 0.109, 0.627 0.005 0.27 0.055, 0.485 0.014 0.22 0.050, 0.395 0.012 0.36 0.093, 0.627 0.008
DBP 0.16 0.009, 0.303 0.037 0.04 − 0.083, 0.160 0.534 0.07 − 0.033, 0.163 0.195 0.02 − 0.133, 0.170 0.809
MAP 0.23 0.056, 0.393 0.009 0.11 − 0.026, 0.253 0.112 0.12 0.004 0.229 0.042 0.13 − 0.042, 0.305 0.138
PP 0.22 0.026, 0.414 0.027 0.24 0.082, 0.403 0.003 0.16 0.033, 0.293 0.014 0.35 0.145, 0.544 0.001
Log glucose 2 × 10–3 − 0.002, 0.006 0.280 3 × 10–3 0, 0.007 0.049 4 × 10–3 0.001, 0.007 0.004 8 × 10–3 0.003, 0.012 4.0 × 10–4†
Log insulin 2 × 10–3 − 0.008, 0.011 0.724 0.01 0.005, 0.020 0.002 0.01 0, 0.012 0.056 2 × 10–3 − 0.008, 0.011 0.722
Total cholesterol − 0.22 − 0.778, 0.332 0.430 − 0.17 − 0.627, 0.291 0.473 − 0.06 − 0.431, 0.309 0.748 − 0.49 − 1.057, 0.080 0.092
Log HDL-C − 3 × 10–4 − 0.004, 0.003 0.855 − 1 × 10–3 − 0.004, 0.002 0.475 1 × 10–3 − 0.001, 0.003 0.444 − 2 × 10–3 − 0.005, 0.002 0.328
LDL-C − 0.38 − 0.894, 0.144 0.157 − 0.15 − 0.579, 0.281 0.498 − 0.23 − 0.576, 0.120 0.199 − 0.77 − 1.303, -0.236 0.005
Log triglycerides 3 × 10–3 − 0.002, 0.009 0.214 1 × 10–3 − 0.004, 0.005 0.758 3 × 10–3 − 0.001, 0.007 0.105 0.01 0.006, 0.017 1.05 × 10–4†
  1. Models are adjusted for age, sex, and familial relatedness
  2. IEAA, intrinsic epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; PP, pulse pressure; HDL-C, high density lipoprotein; LDL-C, low density lipoprotein
  3. Effect sizes (β) correspond to the change in the cardiometabolic risk factor associated with a 1-year increase in the epigenetic age acceleration measure
  4. Associations significant at P < 0.05 are shown in bold; Associations significant at Bonferroni adjusted P < 0.005