Cardiometabolic risk factor (outcome)
|
IEAA
|
EEAA
|
PhenoAA
|
GrimAA
|
---|
β
|
95% CI
|
P value
|
β
|
95% CI
|
P value
|
β
|
95% CI
|
P value
|
β
|
95% CI
|
P value
|
---|
SBP
|
0.37
|
0.109, 0.627
|
0.005†
|
0.27
|
0.055, 0.485
|
0.014
|
0.22
|
0.050, 0.395
|
0.012
|
0.36
|
0.093, 0.627
|
0.008
|
DBP
|
0.16
|
0.009, 0.303
|
0.037
|
0.04
|
− 0.083, 0.160
|
0.534
|
0.07
|
− 0.033, 0.163
|
0.195
|
0.02
|
− 0.133, 0.170
|
0.809
|
MAP
|
0.23
|
0.056, 0.393
|
0.009
|
0.11
|
− 0.026, 0.253
|
0.112
|
0.12
|
0.004 0.229
|
0.042
|
0.13
|
− 0.042, 0.305
|
0.138
|
PP
|
0.22
|
0.026, 0.414
|
0.027
|
0.24
|
0.082, 0.403
|
0.003†
|
0.16
|
0.033, 0.293
|
0.014
|
0.35
|
0.145, 0.544
|
0.001†
|
Log glucose
|
2 × 10–3
|
− 0.002, 0.006
|
0.280
|
3 × 10–3
|
0, 0.007
|
0.049
|
4 × 10–3
|
0.001, 0.007
|
0.004†
|
8 × 10–3
|
0.003, 0.012
|
4.0 × 10–4†
|
Log insulin
|
2 × 10–3
|
− 0.008, 0.011
|
0.724
|
0.01
|
0.005, 0.020
|
0.002†
|
0.01
|
0, 0.012
|
0.056
|
2 × 10–3
|
− 0.008, 0.011
|
0.722
|
Total cholesterol
|
− 0.22
|
− 0.778, 0.332
|
0.430
|
− 0.17
|
− 0.627, 0.291
|
0.473
|
− 0.06
|
− 0.431, 0.309
|
0.748
|
− 0.49
|
− 1.057, 0.080
|
0.092
|
Log HDL-C
|
− 3 × 10–4
|
− 0.004, 0.003
|
0.855
|
− 1 × 10–3
|
− 0.004, 0.002
|
0.475
|
1 × 10–3
|
− 0.001, 0.003
|
0.444
|
− 2 × 10–3
|
− 0.005, 0.002
|
0.328
|
LDL-C
|
− 0.38
|
− 0.894, 0.144
|
0.157
|
− 0.15
|
− 0.579, 0.281
|
0.498
|
− 0.23
|
− 0.576, 0.120
|
0.199
|
− 0.77
|
− 1.303, -0.236
|
0.005†
|
Log triglycerides
|
3 × 10–3
|
− 0.002, 0.009
|
0.214
|
1 × 10–3
|
− 0.004, 0.005
|
0.758
|
3 × 10–3
|
− 0.001, 0.007
|
0.105
|
0.01
|
0.006, 0.017
|
1.05 × 10–4†
|
- Models are adjusted for age, sex, and familial relatedness
- IEAA, intrinsic epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; PP, pulse pressure; HDL-C, high density lipoprotein; LDL-C, low density lipoprotein
- Effect sizes (β) correspond to the change in the cardiometabolic risk factor associated with a 1-year increase in the epigenetic age acceleration measure
- Associations significant at P < 0.05 are shown in bold; †Associations significant at Bonferroni adjusted P < 0.005