Table 2 Association between epigenetic age acceleration and cardiometabolic risk factors in GENOA African Americans

SBP

0.37

0.109, 0.627

0.005^†

0.27

0.055, 0.485

0.014

0.22

0.050, 0.395

0.012

0.36

0.093, 0.627

0.008

DBP

0.16

0.009, 0.303

0.037

0.04

− 0.083, 0.160

0.534

0.07

− 0.033, 0.163

0.195

0.02

− 0.133, 0.170

0.809

MAP

0.23

0.056, 0.393

0.009

0.11

− 0.026, 0.253

0.112

0.12

0.004 0.229

0.042

0.13

− 0.042, 0.305

0.138

PP

0.22

0.026, 0.414

0.027

0.24

0.082, 0.403

0.003^†

0.16

0.033, 0.293

0.014

0.35

0.145, 0.544

0.001^†

Log glucose

2 × 10^–3

− 0.002, 0.006

0.280

3 × 10^–3

0, 0.007

0.049

4 × 10^–3

0.001, 0.007

0.004^†

8 × 10^–3

0.003, 0.012

4.0 × 10^–4†

Log insulin

2 × 10^–3

− 0.008, 0.011

0.724

0.01

0.005, 0.020

0.002^†

0.01

0, 0.012

0.056

2 × 10^–3

− 0.008, 0.011

0.722

Total cholesterol

− 0.22

− 0.778, 0.332

0.430

− 0.17

− 0.627, 0.291

0.473

− 0.06

− 0.431, 0.309

0.748

− 0.49

− 1.057, 0.080

0.092

Log HDL-C

− 3 × 10^–4

− 0.004, 0.003

0.855

− 1 × 10^–3

− 0.004, 0.002

0.475

1 × 10^–3

− 0.001, 0.003

0.444

− 2 × 10^–3

− 0.005, 0.002

0.328

LDL-C

− 0.38

− 0.894, 0.144

0.157

− 0.15

− 0.579, 0.281

0.498

− 0.23

− 0.576, 0.120

0.199

− 0.77

− 1.303, -0.236

0.005^†

Log triglycerides

3 × 10^–3

− 0.002, 0.009

0.214

1 × 10^–3

− 0.004, 0.005

0.758

3 × 10^–3

− 0.001, 0.007

0.105

0.01

0.006, 0.017

1.05 × 10^–4†