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Table 1 Descriptive characteristics of GENOA African Americans (N = 1,100)

From: Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans

  Mean (SD) or N (%)
Female 781 (71.0%)
Age (years) 57.1 (10.6)
Education (years) 12.3 (3.5)
Smoking status
 Never 666 (60.5%)
 Former 255 (23.2%)
 Current 179 (16.3%)
Alcohol consumption (drinks/week) 0.66 (2.6)
BMI (kg/m2) 31.20 (6.6)
Type 2 diabetes 216 (19.6%)
Anti-hypertensive medication use 649 (59.0%)
Hypertension 771 (70.1%)
Epigenetic age acceleration
 IEAA (years) (N = 1099) 0.15 (4.8)
 EEAA (years) 0.27 (5.9)
 PhenoAA (years) (N = 1099) 0.38 (7.2)
 GrimAA (years) (N = 1099) 0.11 (5.0)
Cardiometabolic parameters
 Systolic blood pressure (mmHg) 133.8 (21.6)
 Diastolic blood pressure (mmHg) 77.7 (11.9)
 Mean arterial pulse pressure (mmHg) 96.4 (13.5)
 Pulse pressure (mmHg) 56.2 (17.7)
 Glucose (mg/dl) (N = 883) 109.2 (42.1)
 Insulin (mIU/l) (N = 882) 11.5 (13.4)
 Total cholesterol (mg/dl) (N = 1098) 204.3 (45.2)
 HDL-C (mg/dl) 55.2 (17.9)
 LDL-C (mg/dl) (N = 1076) 120.8 (41.5)
 Triglycerides (mg/dl) (N = 1099) 146.0 (82.1)
CVD 10-year risk scores
 Framingham risk score (%) (N = 945) 14.4 (12.7)
 ASCVD risk equation (%) (N = 988) 11.6 (11.1)
Prevalent CVD at baseline 91 (8.3%)
Incident CVD at follow-up 72 (8.8 per 1000 person-years)
  1. Cardiovascular disease (CVD) was defined as self-reported myocardial infarction, coronary artery revascularization, cerebrovascular events, or surgical carotid artery revascularization
  2. SD, standard deviation; IEAA, intrinsic epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration; BMI, body mass index; HDL-C, high density lipoprotein; LDL-C, low density lipoprotein; CVD, cardiovascular disease; ASCVD, Atherosclerotic cardiovascular disease
  3. Total N = 991 at Phase II and N = 496 at Phase III with DNAm measures