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Table 1 Descriptive characteristics of GENOA African Americans (N = 1,100)

From: Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans

 

Mean (SD) or N (%)

Female

781 (71.0%)

Age (years)

57.1 (10.6)

Education (years)

12.3 (3.5)

Smoking status

 Never

666 (60.5%)

 Former

255 (23.2%)

 Current

179 (16.3%)

Alcohol consumption (drinks/week)

0.66 (2.6)

BMI (kg/m2)

31.20 (6.6)

Type 2 diabetes

216 (19.6%)

Anti-hypertensive medication use

649 (59.0%)

Hypertension

771 (70.1%)

Epigenetic age acceleration

 IEAA (years) (N = 1099)

0.15 (4.8)

 EEAA (years)

0.27 (5.9)

 PhenoAA (years) (N = 1099)

0.38 (7.2)

 GrimAA (years) (N = 1099)

0.11 (5.0)

Cardiometabolic parameters

 Systolic blood pressure (mmHg)

133.8 (21.6)

 Diastolic blood pressure (mmHg)

77.7 (11.9)

 Mean arterial pulse pressure (mmHg)

96.4 (13.5)

 Pulse pressure (mmHg)

56.2 (17.7)

 Glucose (mg/dl) (N = 883)

109.2 (42.1)

 Insulin (mIU/l) (N = 882)

11.5 (13.4)

 Total cholesterol (mg/dl) (N = 1098)

204.3 (45.2)

 HDL-C (mg/dl)

55.2 (17.9)

 LDL-C (mg/dl) (N = 1076)

120.8 (41.5)

 Triglycerides (mg/dl) (N = 1099)

146.0 (82.1)

CVD 10-year risk scores

 Framingham risk score (%) (N = 945)

14.4 (12.7)

 ASCVD risk equation (%) (N = 988)

11.6 (11.1)

Prevalent CVD at baseline

91 (8.3%)

Incident CVD at follow-up

72 (8.8 per 1000 person-years)

  1. Cardiovascular disease (CVD) was defined as self-reported myocardial infarction, coronary artery revascularization, cerebrovascular events, or surgical carotid artery revascularization
  2. SD, standard deviation; IEAA, intrinsic epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration; BMI, body mass index; HDL-C, high density lipoprotein; LDL-C, low density lipoprotein; CVD, cardiovascular disease; ASCVD, Atherosclerotic cardiovascular disease
  3. †Total N = 991 at Phase II and N = 496 at Phase III with DNAm measures