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Table 2 DZNep Treatment Blocks Tumor Progression in the NNK A/J Mouse Model

From: Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention

Treatment Hyperplasia Adenoma Carcinoma Total lesions
Vehicle 4.3 ± 2.6 5.6 ± 2.4 0.3 ± 0.5 10.2 ± 2.8
DZNep 8.1 ± 3.0* 2.5 ± 2.0* 0.0 ± 0 10.6 ± 3.6
EPZ/UNC 5.2 ± 1.7 6.0 ± 2.9 2.1 ± 1.2 13.2 ± 3.8
Control Diet 4.5 ± 1.4 5.9 ± 3.4 0.9 ± 0.9 11.3 ± 3.8
Lovaza 6.6 ± 3.4 5.4 ± 1.8 1.4 ± 1.2 13.3 ± 4.1
  1. Values are number of lesions (mean ± SD) from 12 to 15 mice per group
  2. *p < 0.01 compared to vehicle