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Table 2 DZNep Treatment Blocks Tumor Progression in the NNK A/J Mouse Model

From: Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention

Treatment

Hyperplasia

Adenoma

Carcinoma

Total lesions

Vehicle

4.3 ± 2.6

5.6 ± 2.4

0.3 ± 0.5

10.2 ± 2.8

DZNep

8.1 ± 3.0*

2.5 ± 2.0*

0.0 ± 0

10.6 ± 3.6

EPZ/UNC

5.2 ± 1.7

6.0 ± 2.9

2.1 ± 1.2

13.2 ± 3.8

Control Diet

4.5 ± 1.4

5.9 ± 3.4

0.9 ± 0.9

11.3 ± 3.8

Lovaza

6.6 ± 3.4

5.4 ± 1.8

1.4 ± 1.2

13.3 ± 4.1

  1. Values are number of lesions (mean ± SD) from 12 to 15 mice per group
  2. *p < 0.01 compared to vehicle
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Clinical Epigenetics

ISSN: 1868-7083

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