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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention

Fig. 4

Genetic knock down of EZH2 attenuates carcinogen-induced transformation. shEZH2 knock out clones 6 and 7 show reduced transcription determined by RT-qPCR (a) and reduced levels of protein by Western blot compared to scrambled control (b). Protein levels of EZH2 were quantified by densitometry relative β-Actin (b). Comparison of colony formation between scrambled control and EZH2 knock down clones following 12 weeks of carcinogen treatment (c)

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Clinical Epigenetics

ISSN: 1868-7083

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