Skip to main content
Fig. 1 | Clinical Epigenetics

Fig. 1

From: Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention

Fig. 1

Carcinogen-induced transformation and epigenetic reprogramming of HBEC lines. Comparison of colony formation across HBEC lines after carcinogen treatment (a). The number of genes with increased or decreased expression across transformed HBECs (b). Ingenuity Pathway Analysis was used to identify pathways for the 1369 differentially expressed genes in one or more transformed HBECs (c). Bisulfite sequencing of promoter regions of CST6, ELMO3, KRT19, MALL, PTK6, and RBM35B in HBEC2 and HBEC2T shows increased DNA methylation resulting from transformation (d). Mean ± SEM of ten clones

Back to article page