Table 2 Association of newborn birthweight with 38 CpG sites and gene methylation scores that were significantly associated with maternal smoking during pregnancy in 954 mother–newborn pairs from the Boston Birth Cohort
Gene | CpG* | Associations with birthweighta | ||
|---|---|---|---|---|
Beta | SE | P | ||
GFI1 | cg09662411 | 62.6 | 15.1 | 3.66E−05# |
cg06338710 | 36.5 | 16.1 | 0.020 | |
cg18146737 | 65.5 | 14.9 | 1.29E−05# | |
cg18316974 | 60.4 | 15.0 | 6.37E−05# | |
cg04535902 | 66 | 16.1 | 4.72E−05# | |
cg09935388 | 68.6 | 15.5 | 1.09E−05# | |
cg14179389 | 48.7 | 15.5 | 0.002 | |
GFI1 gene score | 71.5 | 15.6 | 5.17E−06# | |
AHRR | cg05575921 | 92.0 | 15.4 | 3.00E−09# |
cg21161138 | 23.4 | 15.6 | 0.135 | |
CYP1A1 | cg05549655 | − 59.1 | 17.6 | 7.97E−04# |
cg17852385 | − 36.7 | 17.8 | 0.039 | |
cg13570656 | − 50.4 | 16.7 | 0.003 | |
cg12101586 | − 47 | 16.1 | 0.004 | |
cg22549041 | − 32.9 | 16.1 | 0.041 | |
cg11924019 | − 46.6 | 17.9 | 0.010 | |
cg18092474 | − 56.5 | 17.2 | 0.001# | |
CYP1A1 gene score | − 61.3 | 18.0 | 6.84E−04# | |
DHRS3 | cg03546360 | 24.6 | 16.3 | 0.155 |
PRPF38B | cg18011080 | 21.5 | 15.6 | 0.169 |
MEIS1 | cg08791563 | 23.1 | 15.6 | 0.140 |
ST3GAL5 | cg26537885 | 2.54 | 17.8 | 0.886 |
GARS | cg16875104 | 17.8 | 16.3 | 0.274 |
CNTNAP2 | cg25949550 | 6.2 | 15.7 | 0.694 |
FBXO16 | cg12474312 | − 3.8 | 15.6 | 0.808 |
POLR1E | cg14035521 | 47.4 | 15.4 | 0.002 |
GCNT3 | cg25311764 | − 41.2 | 15.5 | 0.008 |
ZNF747 | cg17521795 | 16.3 | 15.4 | 0.291 |
CDH2 | cg03513978 | 42.8 | 15.2 | 0.005 |
cg22332722 | 22.4 | 15.4 | 0.146 | |
ZNF835 | cg08158952 | 20.5 | 14.9 | 0.169 |
ATP9A | cg07339236 | 31.3 | 17.0 | 0.065 |
UFD1L | cg08625065 | 10.4 | 16.2 | 0.518 |
Intergenic CpGs | cg06415891 | − 29.4 | 16.0 | 0.067 |
cg21010202 | 14.7 | 15.5 | 0.343 | |
cg04763519 | − 4.3 | 15.8 | 0.786 | |
cg04565473 | 5.31 | 15.5 | 0.731 | |
cg04598670 | 21.5 | 15.3 | 0.160 | |
cg27447574 | 3.3 | 16.3 | 0.843 | |
cg24061125 | − 19.7 | 14.9 | 0.187 | |